Successful Treatment of Calciphylaxis With Pamidronate

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HOOMAN NAKYSA; Naghshi Zadiyan Rama; MEHRAZMA MITRA; JAHANGIRI FARIBA

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Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2015 | Volume:9 | Issue:1 Page(s): 67-70

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Title

Successful Treatment of Calciphylaxis With Pamidronate

Author(s)

HOOMAN NAKYSA | Naghshi Zadiyan Rama | MEHRAZMA MITRA | JAHANGIRI FARIBA | Issue Writer Certificate

Keywords

hyperphosphatemia

hypocalcemia

calciphylaxis

chronic kidney failure

vascular calcification;bone density conservation agent;debridement

Abstract

calciphylaxis is a complication of chronic kidney disease characterized by necrotic lesion in the skin. Histological examination reveals microcalcification of medium-sized blood vessels. We report on a 21-month-old girl with end-stage renal disease with severe calcium-phosphate imbalance. calciphylaxis process started when she received calcium gluconate intravenously the day before the surgery to correct hypocalcemia and continued progressively despite peritoneal dialysis and forced stopping calcium-containing medication. Pamidronate, 0. 5 mg/kg/d, was administered for 6 days and then once a week for 5 weeks. After 1 week, the skin lesion started to heal and circulation improved, and after 6 weeks, all skin lesions completely recovered. Pamidronate was effective to stop calciphylaxis in this case with advanced renal insufficiency and severe calcium-phosphate imbalance. Medical or surgical debridement are not suggested and lesions might recover without scar by pamidronate.

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APA: Copy

HOOMAN, NAKYSA, Naghshi Zadiyan, Rama, MEHRAZMA, MITRA, & JAHANGIRI, FARIBA. (2015). Successful Treatment of Calciphylaxis With Pamidronate. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 9(1), 67-70. SID. https://sid.ir/paper/309667/en

Vancouver: Copy

HOOMAN NAKYSA, Naghshi Zadiyan Rama, MEHRAZMA MITRA, JAHANGIRI FARIBA. Successful Treatment of Calciphylaxis With Pamidronate. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2015;9(1):67-70. Available from: https://sid.ir/paper/309667/en

IEEE: Copy

NAKYSA HOOMAN, Rama Naghshi Zadiyan, MITRA MEHRAZMA, and FARIBA JAHANGIRI, “Successful Treatment of Calciphylaxis With Pamidronate,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 9, no. 1, pp. 67–70, 2015, [Online]. Available: https://sid.ir/paper/309667/en

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