THE BEHAVIORAL STUDY OF PARKINSON RAT MODEL AFTER TRANSPLANTING BONE MARROW EMBRYONIC STEM CELLS (ES) TO STRIATUM

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HAJI GHASEM KASHANI M.; ALTARIHI T.; MOVAHEDIN M.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2007 | Volume:14 | Issue:70 Page(s): 11-18

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Title

THE BEHAVIORAL STUDY OF PARKINSON RAT MODEL AFTER TRANSPLANTING BONE MARROW EMBRYONIC STEM CELLS (ES) TO STRIATUM

Author(s)

HAJI GHASEM KASHANI M. | ALTARIHI T. | MOVAHEDIN M. | Issue Writer Certificate

Keywords

BONE MARROW STROMAL CELLSQ3

PARKINSON DISEASEQ2

CELL THERAPYQ1

NEUROTOXIN 60HDAQ3

STRIATUMQ3

Abstract

Introduction: Parkinson is a progressive disease gradually deterring the central neural system. I apoptosis the dopaminergic neurons of the dense substantia nigra causing dopamine decrease in the STRIATUM. Application of embryonic stem cells is considered an appropriate treatment for the disease, since these are capable of self-proliferation and transdifferentiation. However, this treatment may lead to the development of tumor and the immunity reaction of the receptor is very severe. Thus, it is illegal and immoral.Materials & Methods: To conduct this study, the marrow stromal cells of the mature rats were isolated and transplanted to the STRIATUM of the Parkinson rats of the same strain. Their swing test in the second, fourth and sixth week after the trauma were evaluated.Result: The behavioral assessment indicated that the Parkinson model rats which had received BONE MARROW STROMAL CELLS had significant differences compared to those which had culture injected into their substantial nigra Their swig test revealed a significant decrease.Conclusion: Somatic embryonic cells are considered a proper treatment for PARKINSON DISEASE. However, the BONE MARROW STROMAL CELLS are much more readily available. Moreover, they can be differentiated and isolated from other cells such as neurons, and are capable of self-proliferation; therefore, are preferable to other treatments.

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APA: Copy

HAJI GHASEM KASHANI, M., ALTARIHI, T., & MOVAHEDIN, M.. (2007). THE BEHAVIORAL STUDY OF PARKINSON RAT MODEL AFTER TRANSPLANTING BONE MARROW EMBRYONIC STEM CELLS (ES) TO STRIATUM. DANESHVAR MEDICINE, 14(70), 11-18. SID. https://sid.ir/paper/30999/en

Vancouver: Copy

HAJI GHASEM KASHANI M., ALTARIHI T., MOVAHEDIN M.. THE BEHAVIORAL STUDY OF PARKINSON RAT MODEL AFTER TRANSPLANTING BONE MARROW EMBRYONIC STEM CELLS (ES) TO STRIATUM. DANESHVAR MEDICINE[Internet]. 2007;14(70):11-18. Available from: https://sid.ir/paper/30999/en

IEEE: Copy

M. HAJI GHASEM KASHANI, T. ALTARIHI, and M. MOVAHEDIN, “THE BEHAVIORAL STUDY OF PARKINSON RAT MODEL AFTER TRANSPLANTING BONE MARROW EMBRYONIC STEM CELLS (ES) TO STRIATUM,” DANESHVAR MEDICINE, vol. 14, no. 70, pp. 11–18, 2007, [Online]. Available: https://sid.ir/paper/30999/en

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