Investigation of TNF-α (rs1800629) in patients with Alopecia Areata

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Khaksar Leila; Tabatabaei Panah Pardis Sadat; AKBARZADEH REZA

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Journal: DANESHVAR MEDICINE Year:2018 | Volume:25 | Issue:136 Page(s): 33-42

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Title

Investigation of TNF-α (rs1800629) in patients with Alopecia Areata

Author(s)

Khaksar Leila | Tabatabaei Panah Pardis Sadat | AKBARZADEH REZA | Issue Writer Certificate

Keywords

Alopecia AreataQ1

Autoimmune diseaseQ2

PolymorphismQ2

TNF-αQ1

PCR-RFLPQ2

Abstract

Background and Objective: Alopecia Areata (AA) is characterized by an autoimmune hair loss usually, but not limited to, the scalp, affecting approximately 1-2% of the general population. Although the etiology and pathogenesis of this disease is still unknown, it is known that TNFα-308G/A Polymorphism can influence the development of AA. The aim of this study was to investigate TNF-α (rs1800629) in patients with Alopecia Areata. Materials and Methods: This study included 30 AA patients and 15 healthy subjects. Genomic DNA was isolated using DNG plus method and DNA was amplified by PCR-RFLP to detect TNFα-308G/A Polymorphism. Furthermore, association of this TNFα-308G/A with demographic factors was assessed. Results: PCR-RFLP results showed that GG was the most frequent genotype in both patient and control groups (P= 0. 816). GA genotype was detected in 30% and 20% of patients and controls, respectively (P= 0. 477). Genotype AA was detected in 6. 7% of controls. Conclusion: The results of TNFα-308G/A Polymorphism showed no significant difference with respect to AA disease and demographic factors (p>0. 05).

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APA: Copy

Khaksar, Leila, Tabatabaei Panah, Pardis Sadat, & AKBARZADEH, REZA. (2018). Investigation of TNF-α (rs1800629) in patients with Alopecia Areata. DANESHVAR MEDICINE, 25(136 ), 33-42. SID. https://sid.ir/paper/31049/en

Vancouver: Copy

Khaksar Leila, Tabatabaei Panah Pardis Sadat, AKBARZADEH REZA. Investigation of TNF-α (rs1800629) in patients with Alopecia Areata. DANESHVAR MEDICINE[Internet]. 2018;25(136 ):33-42. Available from: https://sid.ir/paper/31049/en

IEEE: Copy

Leila Khaksar, Pardis Sadat Tabatabaei Panah, and REZA AKBARZADEH, “Investigation of TNF-α (rs1800629) in patients with Alopecia Areata,” DANESHVAR MEDICINE, vol. 25, no. 136 , pp. 33–42, 2018, [Online]. Available: https://sid.ir/paper/31049/en

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