The effect of acetyl L-carnitine on gliosis reaction after spinal cord injury using a compression model in adult rats

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Jamshidi Sadra; HESHMATI MARJAN; JALALI NADOUSHAN MOHAMMADREZA

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2018 | Volume:25 | Issue:136 Page(s): 15-24

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Title

The effect of acetyl L-carnitine on gliosis reaction after spinal cord injury using a compression model in adult rats

Author(s)

Jamshidi Sadra | HESHMATI MARJAN | JALALI NADOUSHAN MOHAMMADREZA | Issue Writer Certificate

Keywords

Acetyl L-carnitineQ1

GliosisQ3

Adult RatQ2

Abstract

Background and Objective: Contusion injury causes a major variety of functional and sensory disorders. In this research, we tried to study histological changes after performing contusion model in spinal cord. For this reason, we investigated the effect of Acetyl L-carnitine on Gliosis reaction by using immunohistochemistry method for GFAP and CNPase after spinal cord injury(SCI). Materials and Methods: In this study, 24 male adult Sprague-Dawley rats were randomly divided into 4 groups. Laminectomy at T9-T11 was done in all of the rats and based on control groups or study groups, normal saline or acetyl Lcarnitine (300 mg/kg) was injected. In study groups, SCI was done by 30 gr compression. After 4 weeks, spinal cords were extracted for morphometry and immunohistochemistry study and data were analyzed using t test and ANOVA at p<0. 05. Results: Motoneurons reduced after SCI and Acetyl L-carnitine reduced this reduction in addition to reduction of astrocytes (p<0. 05). Conclusion: For the first time it was shown that in Gliosis reaction, acetyl Lcarnitine could reduce astrocytes and increase oligodendrocytes (about 3 times) and this improvement may be due to myelin production and also due to better conduction. Further study is needed to distinguish synapse conduction.

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APA: Copy

Jamshidi, Sadra, HESHMATI, MARJAN, & JALALI NADOUSHAN, MOHAMMADREZA. (2018). The effect of acetyl L-carnitine on gliosis reaction after spinal cord injury using a compression model in adult rats. DANESHVAR MEDICINE, 25(136 ), 15-24. SID. https://sid.ir/paper/31052/en

Vancouver: Copy

Jamshidi Sadra, HESHMATI MARJAN, JALALI NADOUSHAN MOHAMMADREZA. The effect of acetyl L-carnitine on gliosis reaction after spinal cord injury using a compression model in adult rats. DANESHVAR MEDICINE[Internet]. 2018;25(136 ):15-24. Available from: https://sid.ir/paper/31052/en

IEEE: Copy

Sadra Jamshidi, MARJAN HESHMATI, and MOHAMMADREZA JALALI NADOUSHAN, “The effect of acetyl L-carnitine on gliosis reaction after spinal cord injury using a compression model in adult rats,” DANESHVAR MEDICINE, vol. 25, no. 136 , pp. 15–24, 2018, [Online]. Available: https://sid.ir/paper/31052/en

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