Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney

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FAKOURIAN A.; MATINHOMAEE H.; AZARBAYJANI M.A.; FARZANEGI P.

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Journal: Armaghane Danesh Year:2019 | Volume:24 | Issue:3 (134) Page(s): 293-305

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Title

Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney

Author(s)

FAKOURIAN A. | MATINHOMAEE H. | AZARBAYJANI M.A. | FARZANEGI P. | Issue Writer Certificate

Keywords

Aerobic trainingQ1

L-carnitineQ1

DiabetesQ2

SODQ2

GPXQ2

MDAQ2

KidneyQ2

Abstract

Background & aim: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of Aerobic training and consumption of L-carnitine on some of the oxidative stress factors in diabetic Kidney. Methods: In the present experimental study, 45 male Wistar rats(200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving L-carnitine, 5) diabetic group of Aerobic training, 6) diabetic group of Aerobic training and receiving L-carnitine. Rats were diabetic peritoneal injected with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily of 100 mg of L-carnitine orally. The aerobic exercise protocol included five sessions per week on the treadmill. Data were analyzed by two way ANOVA and Tukey post hoc test at P <0. 05. Results: Six weeks of aerobic exercise, supplementation of L-carnitine and combined intervention of aerobic exercise and supplementation of L-carnitine do not have a significant effect on MDA and SOD factors of Kidney tissue in diabetic rats(p>0. 05). However, six weeks of aerobic exercise had a significant effect on GPX factor in Kidney tissue in diabetic rats (p=0. 003). Moreover, supplementation and combined intervention of aerobic exercise and supplementation of L-carnitine did not have a significant effect on GPX factor of Kidney tissue in diabetic rats (p>0. 05) Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on the body, antioxidant defense system and decreases oxidative stress in rats with type 2 Diabetes.

Cites

The Effect of Aerobic Training and Tribulus terrestris Extract on Some Oxidative Stress Indices in the Heart Tissue of Male Wistar Rats Poisoned with Hydrogen Peroxide

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APA: Copy

FAKOURIAN, A., MATINHOMAEE, H., AZARBAYJANI, M.A., & FARZANEGI, P.. (2019). Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney. ARMAGHAN DANESH, 24(3 (134) ), 293-305. SID. https://sid.ir/paper/361009/en

Vancouver: Copy

FAKOURIAN A., MATINHOMAEE H., AZARBAYJANI M.A., FARZANEGI P.. Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney. ARMAGHAN DANESH[Internet]. 2019;24(3 (134) ):293-305. Available from: https://sid.ir/paper/361009/en

IEEE: Copy

A. FAKOURIAN, H. MATINHOMAEE, M.A. AZARBAYJANI, and P. FARZANEGI, “Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney,” ARMAGHAN DANESH, vol. 24, no. 3 (134) , pp. 293–305, 2019, [Online]. Available: https://sid.ir/paper/361009/en

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