EVALUATION OF GO LYMPHOCYTE RADIOSENSITIVITY AGAINST GAMMA RAY IN BREAST CANCER PATIENTS USING CYTOCHALASIN BLOCKED MICRONUCLEUS ASSAY

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HAERI S.A.; EMRANIPOUR R.

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Journal: DANESHVAR MEDICINE Year:2001 | Volume:8 | Issue:35 Page(s): 25-32

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Title

EVALUATION OF GO LYMPHOCYTE RADIOSENSITIVITY AGAINST GAMMA RAY IN BREAST CANCER PATIENTS USING CYTOCHALASIN BLOCKED MICRONUCLEUS ASSAY

Author(s)

HAERI S.A. | | EMRANIPOUR R. | Issue Writer Certificate

Keywords

RADIOSENSITIVITYQ3

BREAST CANCERQ2

MICRONUCLEI ASSAYQ4

LYMPHOCYTEQ3

Abstract

Nowadays, mammography is the Only existing method for screening BREAST CANCER. Besides diagnostic limitations of mammography, this procedure may increase cancer risk in predisposed individuals -duello their exposure to ionizing radiation. Structural changes in chromosomes can activate oncogenes and deactivate tumor suppressor genes and therefore constitute an important mechanism for inducing cancer. The extent of chromosomal damages induced. by ionizing radiation constitutes a criterion to evaluate radio sensitivity and predisposition to cancer. In order to estimate this radio sensitivity, cytogenesis response of LYMPHOCYTEs from 30 BREAST CANCER patients before radiotherapy and chemotherapy to 3 Gray gamma-irradiation was compared with 30 healthy individuals. The assessment was peformed using MICRONUCLEI ASSAY, a reliable method to examine cytogenetic effects of physico-chemical agents.Lymphocytes were stimulated with a mitogen 6 hour after irradiation.Cytochalasin-B was added 24 hours after the stimulation to inhibit the cytokines is of ymphocytes and in the 90th hour cells were harvested. Micronuclei count per 1000 binuclear LYMPHOCYTEs showed that. the average number of spontaneous and co/Tested micronuclei (after irradiation and subtraction of .spontaneous micronuclei) was higher in BREAST CANCER patients than control group (P<0.001). Considering the values higher than "Mean + 2SD" in control group, 33 percent of patients and 3 percent of control group have shown high radio sensitivity. Regarding the low incidence of mutation in highly penetrant genes ATM and BRCA1/2, a large number of patients with BREAST CANCER may carry low penetrating genes that increase susceptibility to BREAST CANCER. Cytogenetic studies may be used in future to screen individuals with risk of contracting BREAST CANCER and to protect predisposed individuals from it.

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APA: Copy

HAERI, S.A., EMRANIPOUR, R.. (2001). EVALUATION OF GO LYMPHOCYTE RADIOSENSITIVITY AGAINST GAMMA RAY IN BREAST CANCER PATIENTS USING CYTOCHALASIN BLOCKED MICRONUCLEUS ASSAY. DANESHVAR MEDICINE, 8(35), 25-32. SID. https://sid.ir/paper/31091/en

Vancouver: Copy

HAERI S.A., EMRANIPOUR R.. EVALUATION OF GO LYMPHOCYTE RADIOSENSITIVITY AGAINST GAMMA RAY IN BREAST CANCER PATIENTS USING CYTOCHALASIN BLOCKED MICRONUCLEUS ASSAY. DANESHVAR MEDICINE[Internet]. 2001;8(35):25-32. Available from: https://sid.ir/paper/31091/en

IEEE: Copy

S.A. HAERI, R. EMRANIPOUR, “EVALUATION OF GO LYMPHOCYTE RADIOSENSITIVITY AGAINST GAMMA RAY IN BREAST CANCER PATIENTS USING CYTOCHALASIN BLOCKED MICRONUCLEUS ASSAY,” DANESHVAR MEDICINE, vol. 8, no. 35, pp. 25–32, 2001, [Online]. Available: https://sid.ir/paper/31091/en

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