THE EFFECT OF OCTACALCIUM PHOSPHATE (OCP) ON THE REPAIR OF PARIETAL BONE DEFECTS IN RATS

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SARGHOLZAIE F.; SOBHANI A.; ETESAM F.; AKBARI M.; NIKNAFS B.; MEHRANNIA K.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2001 | Volume:8 | Issue:35 Page(s): 47-53

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Title

THE EFFECT OF OCTACALCIUM PHOSPHATE (OCP) ON THE REPAIR OF PARIETAL BONE DEFECTS IN RATS

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Keywords

OCTACALCIUM PHOSPHATEQ4

INTRAMEMBRANOUS OSTEOGENESISQ4

PARIETAL BONEQ2

RATQ2

Abstract

In order to evaluate bone induction and repair in cranial bone defects by the use of OCTACALCIUM PHOSPHATE (OCP), the authors used 40 young male Sprague Dawley RATs (5-6 weeks age) The OCP was which they made use of it in the present study was prepared by a method, namely legeraus method. A defect with 5mm diameter was produced in PARIETAL BONEs and then 5mg OCP was implanted in the place of the defect. On the 5th 7th 14th and st days after the operation, the specimens were taken out of the defect.After processing the tissues by routine procedures, the authors prepared 5 micron sections of the samples, stained them with H&E and finally studied the sections by light microscope. On the 5th day, they noticed inflammatory cells around the implanted OCP. On the 7th day after the operation, osteogenesis was initiated from the margin of the defect. And finally on the 14th day and the days after, in addition to bone formation from the margins towards the centre, they observed more oppositions of new bones locally around the OCP particles. At the end of 21st day, almost all of the OCP particles were absorbed and bone trabeculae, marrow cavities, bone marrow tissues were appeared. As the findings show OCP could stimulate bone induction and new bone formation in bone defects, so it seems that OCP could be used in the repair of cranial bone defects.

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APA: Copy

SARGHOLZAIE, F., SOBHANI, A., ETESAM, F., AKBARI, M., NIKNAFS, B., & MEHRANNIA, K.. (2001). THE EFFECT OF OCTACALCIUM PHOSPHATE (OCP) ON THE REPAIR OF PARIETAL BONE DEFECTS IN RATS. DANESHVAR MEDICINE, 8(35), 47-53. SID. https://sid.ir/paper/31092/en

Vancouver: Copy

SARGHOLZAIE F., SOBHANI A., ETESAM F., AKBARI M., NIKNAFS B., MEHRANNIA K.. THE EFFECT OF OCTACALCIUM PHOSPHATE (OCP) ON THE REPAIR OF PARIETAL BONE DEFECTS IN RATS. DANESHVAR MEDICINE[Internet]. 2001;8(35):47-53. Available from: https://sid.ir/paper/31092/en

IEEE: Copy

F. SARGHOLZAIE, A. SOBHANI, F. ETESAM, M. AKBARI, B. NIKNAFS, and K. MEHRANNIA, “THE EFFECT OF OCTACALCIUM PHOSPHATE (OCP) ON THE REPAIR OF PARIETAL BONE DEFECTS IN RATS,” DANESHVAR MEDICINE, vol. 8, no. 35, pp. 47–53, 2001, [Online]. Available: https://sid.ir/paper/31092/en

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