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Information Journal Paper

Title

CEFAZOLIN-GENTAMICIN VERSUS VANCOMYCIN-CEFTAZIDIME EYE DROPS FOR BACTERIAL CORNEAL ULCERS; A RANDOMIZED CLINICAL TRIAL

Pages

  19-23

Abstract

 Purpose: To compare the efficacy of topical CEFAZOLIN-gentamicin versus VANCOMYCINceftazidime for treatment of bacterial CORNEAL ULCERs.Methods: This randomized double-masked clinical trial was performed on consecutive patients with bacterial CORNEAL ULCERs referred to Feiz Hospital, Isfahan, Iran from 2004 to 2005. Patients were randomly assigned to CEFAZOLIN-gentamicin or VANCOMYCIN-ceftazidime eye drops in a masked fashion. Outcome measures included time for resolution of stromal infiltration, re-epithelization of the epithelial defect, and clearance of anterior chamber inflammation as well as culture results and complications.Results: The study included 89 eyes of 89 patients with bacterial CORNEAL ULCERs consisting of 57 (64%) male and 32 (36%) female subjects. Specimens were culturenegative in 46% of cases. Forty-one eyes received CEFAZOLIN-gentamicin and 48 eyes were treated with VANCOMYCIN-ceftazidime. Time for resolution of stromal infiltration was 17.7±4.3 days versus 13.8±3.6 days (P=0.04), time to complete re-epithelization was  13.2±3.1 days versus 9.6±2.7 days (P=0.01) and time for clearing of the anterior chamber was 11.6±2.9 days versus 8.1±2.3 days (P=0.04) in the CEFAZOLIN-gentamicin and VANCOMYCIN-ceftazidime groups, respectively. The most common complaint related to the medications was ocular burning in 73.1% of patients treated with CEFAZOLINgentamicin and 62.9% of cases receiving VANCOMYCIN-ceftazidime (P=0.007).Conclusion: VANCOMYCIN-ceftazidime eye drops seem to be more effective than CEFAZOLIN-gentamicin eye drops for the treatment of bacterial CORNEAL ULCERs and are probably better tolerated locally.

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    Cite

    APA: Copy

    DEHGHANI, A.R., FAZEL, F., AKHLAGHI, M.R., GHANBARI, H.A., ILANLOU, M.R., & AHMADI AZAD, D.. (2009). CEFAZOLIN-GENTAMICIN VERSUS VANCOMYCIN-CEFTAZIDIME EYE DROPS FOR BACTERIAL CORNEAL ULCERS; A RANDOMIZED CLINICAL TRIAL. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 4(1), 19-23. SID. https://sid.ir/paper/311281/en

    Vancouver: Copy

    DEHGHANI A.R., FAZEL F., AKHLAGHI M.R., GHANBARI H.A., ILANLOU M.R., AHMADI AZAD D.. CEFAZOLIN-GENTAMICIN VERSUS VANCOMYCIN-CEFTAZIDIME EYE DROPS FOR BACTERIAL CORNEAL ULCERS; A RANDOMIZED CLINICAL TRIAL. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2009;4(1):19-23. Available from: https://sid.ir/paper/311281/en

    IEEE: Copy

    A.R. DEHGHANI, F. FAZEL, M.R. AKHLAGHI, H.A. GHANBARI, M.R. ILANLOU, and D. AHMADI AZAD, “CEFAZOLIN-GENTAMICIN VERSUS VANCOMYCIN-CEFTAZIDIME EYE DROPS FOR BACTERIAL CORNEAL ULCERS; A RANDOMIZED CLINICAL TRIAL,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 4, no. 1, pp. 19–23, 2009, [Online]. Available: https://sid.ir/paper/311281/en

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