OUTCOMES OF PHOTOREFRACTIVE KERATECTOMY WITH INTRAOPERATIVE MITOMYCIN-C

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GHOREYSHI MANOUCHEHR; ATARZADEH HOSSEIN; ZANDI A.R.; MOEINI H.A.; TAVAKOLI MAHDI; FESHARAKI H.; NASR ELAHI K.

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Journal: Journal of Ophthalmic and Vision Research Year:2009 | Volume:4 | Issue:3 Page(s): 142-146

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Title

OUTCOMES OF PHOTOREFRACTIVE KERATECTOMY WITH INTRAOPERATIVE MITOMYCIN-C

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Keywords

PHOTOREFRACTIVE KERATECTOMY

MITOMYCIN

Abstract

Purpose: To report the efficacy, safety, predictability and complications of PHOTOREFRACTIVE KERATECTOMY (PRK) with intraoperative application of MITOMYCIN-C (MMC).Methods: This historical cohort study was performed on 1,250 eyes of 625 patients who underwent PRK using the Technolas 217 excimer laser machine by a single surgeon with intraoperative use of MMC 0.02% up to 2 minutes, depending on depth of ablation. A complete ophthalmologic examination was performed which included refraction, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA) and slitlamp biomicroscopy. Outcomes were analyzed after one year of follow-up. Results: The mean preoperative spherical equivalent refractive error was -4.85±2.27 (range, -2.50 to -13.5) diopters (D). Mean depth of ablation was 89±22 microns and mean time to reepithelialization was 4.5±1.7 days. At final follow-up, UCVA of 20/20 and 20/40 or more was achieved in 92.1% and 99.2% of eyes, respectively. One year postoperatively, 69.4% and 91% of eyes were within ±0.50 D and ±1.00 D of emmetropia. Overall, 62 eyes (4.9%) developed one or two lines of decrease in BCVA, and 50 eyes (4%) developed corneal haze which was grade 1 or 2 in most cases; grade 3 and 4 corneal haze was found in 4 and 2 eyes, respectively. No other adverse event was noted during the study period.Conclusion: PRK with intraoperative application of MMC provides excellent visual outcomes with acceptable safety and predictability, and entails minimal side effects.

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APA: Copy

GHOREYSHI, MANOUCHEHR, ATARZADEH, HOSSEIN, ZANDI, A.R., MOEINI, H.A., TAVAKOLI, MAHDI, FESHARAKI, H., & NASR ELAHI, K.. (2009). OUTCOMES OF PHOTOREFRACTIVE KERATECTOMY WITH INTRAOPERATIVE MITOMYCIN-C. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 4(3), 142-146. SID. https://sid.ir/paper/311378/en

Vancouver: Copy

GHOREYSHI MANOUCHEHR, ATARZADEH HOSSEIN, ZANDI A.R., MOEINI H.A., TAVAKOLI MAHDI, FESHARAKI H., NASR ELAHI K.. OUTCOMES OF PHOTOREFRACTIVE KERATECTOMY WITH INTRAOPERATIVE MITOMYCIN-C. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2009;4(3):142-146. Available from: https://sid.ir/paper/311378/en

IEEE: Copy

MANOUCHEHR GHOREYSHI, HOSSEIN ATARZADEH, A.R. ZANDI, H.A. MOEINI, MAHDI TAVAKOLI, H. FESHARAKI, and K. NASR ELAHI, “OUTCOMES OF PHOTOREFRACTIVE KERATECTOMY WITH INTRAOPERATIVE MITOMYCIN-C,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 4, no. 3, pp. 142–146, 2009, [Online]. Available: https://sid.ir/paper/311378/en

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