TOPICAL INTERFERON ALPHA‑2B FOR TREATMENT OF NONINVASIVE OCULAR SURFACE SQUAMOUS NEOPLASIA WITH 360OLIMBAL INVOLVEMENT

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ZAREI GHANAVATI SIAMAK; ALIZADEH REZA; DENG SOPHIE X.

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Paper Information

Journal: JOURNAL OF OPHTHALMIC AND VISION RESEARCH Year:2014 | Volume:9 | Issue:4 Page(s): 423-426

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Title

TOPICAL INTERFERON ALPHA‑2B FOR TREATMENT OF NONINVASIVE OCULAR SURFACE SQUAMOUS NEOPLASIA WITH 360OLIMBAL INVOLVEMENT

Author(s)

ZAREI GHANAVATI SIAMAK | ALIZADEH REZA | DENG SOPHIE X. | Issue Writer Certificate

Keywords

CONJUNCTIVAL INTRAEPITHELIAL NEOPLASIA

INTERFERON ALPHA 2B

OCULAR SURFACE SQUAMOUS NEOPLASIA

Abstract

Purpose: To report the results of topical interferon alpha‑2b (IFNa2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360o limbal involvement.Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360o limbal involvement received topical IFNa2b (3 million IU/ml, 4 times daily) and were followed from 8 to 12 months. Outcome measures included resolution of the lesion, relief of symptoms, systemic and ocular side effects, and recurrence rate.Results: Five patients including 4 primary OSSNs and one recurrent OSSN received topical interferon alpha‑2b. The mean age was 60.2 (range: 52–73) years and mean follow up duration was 10.2 months.Clinical resolution of the tumor occurred in all cases 2 months after initiation of treatment and no patient developed ocular or systemic complications. No recurrence of OSSN developed during the follow up period.Conclusion: Topical recombinant IFNα2b appears to be an effective alternative treatment for OSSN with 360o limbal involvement. This approach precludes the high risk of limbal stem cell deficiency which results from surgical excision or topical chemotherapeutic agents.

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APA: Copy

ZAREI GHANAVATI, SIAMAK, ALIZADEH, REZA, & DENG, SOPHIE X.. (2014). TOPICAL INTERFERON ALPHA?2B FOR TREATMENT OF NONINVASIVE OCULAR SURFACE SQUAMOUS NEOPLASIA WITH 360^OLIMBAL INVOLVEMENT. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 9(4), 423-426. SID. https://sid.ir/paper/311571/en

Vancouver: Copy

ZAREI GHANAVATI SIAMAK, ALIZADEH REZA, DENG SOPHIE X.. TOPICAL INTERFERON ALPHA?2B FOR TREATMENT OF NONINVASIVE OCULAR SURFACE SQUAMOUS NEOPLASIA WITH 360^OLIMBAL INVOLVEMENT. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2014;9(4):423-426. Available from: https://sid.ir/paper/311571/en

IEEE: Copy

SIAMAK ZAREI GHANAVATI, REZA ALIZADEH, and SOPHIE X. DENG, “TOPICAL INTERFERON ALPHA?2B FOR TREATMENT OF NONINVASIVE OCULAR SURFACE SQUAMOUS NEOPLASIA WITH 360^OLIMBAL INVOLVEMENT,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 9, no. 4, pp. 423–426, 2014, [Online]. Available: https://sid.ir/paper/311571/en

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