STUDY OF SURROGACY VALIDATION OF TH1, TH2 IN LONG-TERM SKIN EFFECTS OF EXPOSURE TO MUSTARD GAS

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JALAEI SHOHREH; FAGHIHZADEH S.; GHAZANFARI T.; ESKANDARI FARZAD; YARAEE ROYA; MOEIN ATHAR; DAVOUDI SEYED MASOUD; SOROUSH MOHAMMAD REZA; FOROUTAN ABAS; NAGHIZADEH MOHAMMAD MAHDI

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Journal: DANESHVAR MEDICINE Year:2009 | Volume:16 | Issue:79 Page(s): 11-18

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Title

STUDY OF SURROGACY VALIDATION OF TH1, TH2 IN LONG-TERM SKIN EFFECTS OF EXPOSURE TO MUSTARD GAS

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Keywords

SURROGATE ENDPOINTSQ3

INDIVIDUAL-LEVEL VALIDITYQ3

CHEMICAL VICTIMSQ2

BAYES FACTORQ3

MUSTARD GASQ3

CYTOKINE TH1Q2

TH2Q2

Abstract

Background & Objective: We study Surrogacy validation of Th1 and TH2, when the true endpoint is Long-term Skin Effects of Exposure to MUSTARD GAS based on “Martyrs and Veterans Affair” assignment.Materials & Methods: This study is a part of Sardasht-Iran cohort study. 327 CHEMICAL VICTIMS of sulfur mustard from Sardasht and 128 controlled, totally 500 persons, are studied.Results: Trial-Level surrogacy validation of “IL2 Mitogen, IFN-g Mitogen-Nill, IFN-g Mitogen, IL2 Mitogen - Nill” are more than %80. Individual -Level surrogacy of these factors are not enough.Conclusion: Based on our analysis, At the trial-level, we can expect that effects of Exposure to MUSTARD GAS on skin in Long time (based on “Martyrs and Veterans Affair” assignment) be translated into effects of Exposure to MUSTARD GAS on each of “IL2 Mitogen, IFN-g Mitogen - Nill, IFN-g Mitogen, IL2 Mitogen - Nill” factors, with these factors being easier to interpret clinically. At the individual-level surrogacy we don’t find any relationship between the two endpoints, conditioning upon Mustard exposure

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APA: Copy

JALAEI, SHOHREH, FAGHIHZADEH, S., GHAZANFARI, T., ESKANDARI, FARZAD, YARAEE, ROYA, MOEIN, ATHAR, DAVOUDI, SEYED MASOUD, SOROUSH, MOHAMMAD REZA, FOROUTAN, ABAS, & NAGHIZADEH, MOHAMMAD MAHDI. (2009). STUDY OF SURROGACY VALIDATION OF TH1, TH2 IN LONG-TERM SKIN EFFECTS OF EXPOSURE TO MUSTARD GAS. DANESHVAR MEDICINE, 16(79), 11-18. SID. https://sid.ir/paper/31169/en

Vancouver: Copy

JALAEI SHOHREH, FAGHIHZADEH S., GHAZANFARI T., ESKANDARI FARZAD, YARAEE ROYA, MOEIN ATHAR, DAVOUDI SEYED MASOUD, SOROUSH MOHAMMAD REZA, FOROUTAN ABAS, NAGHIZADEH MOHAMMAD MAHDI. STUDY OF SURROGACY VALIDATION OF TH1, TH2 IN LONG-TERM SKIN EFFECTS OF EXPOSURE TO MUSTARD GAS. DANESHVAR MEDICINE[Internet]. 2009;16(79):11-18. Available from: https://sid.ir/paper/31169/en

IEEE: Copy

SHOHREH JALAEI, S. FAGHIHZADEH, T. GHAZANFARI, FARZAD ESKANDARI, ROYA YARAEE, ATHAR MOEIN, SEYED MASOUD DAVOUDI, MOHAMMAD REZA SOROUSH, ABAS FOROUTAN, and MOHAMMAD MAHDI NAGHIZADEH, “STUDY OF SURROGACY VALIDATION OF TH1, TH2 IN LONG-TERM SKIN EFFECTS OF EXPOSURE TO MUSTARD GAS,” DANESHVAR MEDICINE, vol. 16, no. 79, pp. 11–18, 2009, [Online]. Available: https://sid.ir/paper/31169/en

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