COMPARISON OF THE RESULTS OF HIERARCHICAL AND NON-HIERARCHICAL CLUSTERING OF PROTEINS ASSOCIATED WITH CANCERS OF ESOPHAGUS, STOMACH AND COLON VIA SIMILARITY OF GENE ONTOLOGY ANNOTATION

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ALAVIMAJD HAMID; ZARNEGARNIA YALDA; REZAIE MOSTAFA; KHEIR NASIBEH; KHADEM MABOUDI ALIAKBAR

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Journal: DANESHVAR MEDICINE Year:2010 | Volume:17 | Issue:88 Page(s): 17-30

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Title

COMPARISON OF THE RESULTS OF HIERARCHICAL AND NON-HIERARCHICAL CLUSTERING OF PROTEINS ASSOCIATED WITH CANCERS OF ESOPHAGUS, STOMACH AND COLON VIA SIMILARITY OF GENE ONTOLOGY ANNOTATION

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Keywords

BIOINFORMATICSQ2

GENE ONTOLOGY ANNOTATIONQ3

CLUSTERINGQ2

GASTROINTESTINAL SYSTEM CANCERSQ2

Abstract

Background and Objective: Using proteomic methodologies and advent of high-throughput (HTP) investigation of proteins has created a need for new approaches in BIOINFORMATICS analysis of experimental results. Cluster analysis is a suitable statistical procedure that can be useful for analyzing these data sets.Materials and Methods: In this research study, the identified proteins associated with esophagus, stomach and colon cancers were analyzed with the hierarchical and non-hierarchical CLUSTERING procedures. Proteins were clustered for three aspects of gene ontology and results were compared.Results: Despite non-substantial silhouette widths for the entire dataset, most of the proteins in each cluster have remarkable biological communions. According to the results, it was evident that CLUSTERING methods can reveal novel annotation patterns within dataset that would not have been identified otherwise.Conclusion: Considering hierarchical and non-hierarchical CLUSTERING, results show that the CLUSTERING methods have similar results. Maybe we can say because of the introducing representative proteins for each cluster, the partitioning method operating with the greatest nicety while AGNES procedure is simpler. Furthermore, it was clear that the proteins were clustered via their cellular component similarities have also biological and functional similarities which this requires more researches.

Cites

CLASIFICATION OF CUSTUMERS OF INTERNET SERVICES, USING DATA MINING ALGORITHMS

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APA: Copy

ALAVIMAJD, HAMID, ZARNEGARNIA, YALDA, REZAIE, MOSTAFA, KHEIR, NASIBEH, & KHADEM MABOUDI, ALIAKBAR. (2010). COMPARISON OF THE RESULTS OF HIERARCHICAL AND NON-HIERARCHICAL CLUSTERING OF PROTEINS ASSOCIATED WITH CANCERS OF ESOPHAGUS, STOMACH AND COLON VIA SIMILARITY OF GENE ONTOLOGY ANNOTATION. DANESHVAR MEDICINE, 17(88), 17-30. SID. https://sid.ir/paper/31181/en

Vancouver: Copy

ALAVIMAJD HAMID, ZARNEGARNIA YALDA, REZAIE MOSTAFA, KHEIR NASIBEH, KHADEM MABOUDI ALIAKBAR. COMPARISON OF THE RESULTS OF HIERARCHICAL AND NON-HIERARCHICAL CLUSTERING OF PROTEINS ASSOCIATED WITH CANCERS OF ESOPHAGUS, STOMACH AND COLON VIA SIMILARITY OF GENE ONTOLOGY ANNOTATION. DANESHVAR MEDICINE[Internet]. 2010;17(88):17-30. Available from: https://sid.ir/paper/31181/en

IEEE: Copy

HAMID ALAVIMAJD, YALDA ZARNEGARNIA, MOSTAFA REZAIE, NASIBEH KHEIR, and ALIAKBAR KHADEM MABOUDI, “COMPARISON OF THE RESULTS OF HIERARCHICAL AND NON-HIERARCHICAL CLUSTERING OF PROTEINS ASSOCIATED WITH CANCERS OF ESOPHAGUS, STOMACH AND COLON VIA SIMILARITY OF GENE ONTOLOGY ANNOTATION,” DANESHVAR MEDICINE, vol. 17, no. 88, pp. 17–30, 2010, [Online]. Available: https://sid.ir/paper/31181/en

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