Primary Atypical Lipomatous Tumor of the Orbit: A Case Report

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Dworak Douglas P.; Patel Shyam A.; Chennuri Rohini; Falco Daniel

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Journal Paper

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Journal: Journal of Ophthalmic and Vision Research Year:2018 | Volume:13 | Issue:1 Page(s): 78-80

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Title

Primary Atypical Lipomatous Tumor of the Orbit: A Case Report

Author(s)

Dworak Douglas P. | Patel Shyam A. | Chennuri Rohini | Falco Daniel | Issue Writer Certificate

Keywords

Atypical Lipomatous Tumor

Orbital Liposarcoma

Primary Orbital ALT

Primary Orbital Liposarcoma

Well‑

differentiated Liposarcoma

Abstract

Purpose: To describe a case of primary atypical orbital lipomatous tumor (ALT). Case Report: A 35‑ year‑ old man presented with a two‑ month history of left eye proptosis and vertical diplopia. His visual acuity was 20/30 OD and 20/60 OS. External examination showed proptosis and downward displacement of the left eye with mild lid erythema. Extraocular movements were reduced in the left eye, with 10% and 70% motility in upgaze and abduction/adduction, respectively. Imaging showed a mass (22 × 16 × 46 mm) in the superior left orbit that infiltrated the orbital fat and the superior rectus muscle. A biopsy of the mass showed mature adipose tissue intermingled with fibrous zones of hyperchromatic stromal cells with nuclear atypia. Fluorescence in situ hybridization analysis demonstrated positive amplification for MDM2/CEP12. The MDM2 to CEP12 ratio was 5: 7. A diagnosis of ALT was confirmed. An orbital exenteration was recommended, which the patient declined. Conclusion: Although rare, the differential for unilateral proptosis with or without diplopia should include Orbital Liposarcomas including the ALT subtype. Imaging, biopsy, staining, and/or FISH analysis for proto‑ oncogenes can assist with diagnosis and staging, while the standard treatment is exenteration.

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APA: Copy

Dworak, Douglas P., Patel, Shyam A., Chennuri, Rohini, & Falco, Daniel. (2018). Primary Atypical Lipomatous Tumor of the Orbit: A Case Report. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 13(1), 78-80. SID. https://sid.ir/paper/311829/en

Vancouver: Copy

Dworak Douglas P., Patel Shyam A., Chennuri Rohini, Falco Daniel. Primary Atypical Lipomatous Tumor of the Orbit: A Case Report. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2018;13(1):78-80. Available from: https://sid.ir/paper/311829/en

IEEE: Copy

Douglas P. Dworak, Shyam A. Patel, Rohini Chennuri, and Daniel Falco, “Primary Atypical Lipomatous Tumor of the Orbit: A Case Report,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 13, no. 1, pp. 78–80, 2018, [Online]. Available: https://sid.ir/paper/311829/en

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