COMPARING THE EFFICACY OF ADD-ON NORTRYPTILINE WITH TRIIODOTHYRONINE IN THE MANAGEMENT OF CITALOPRAM-RESISTANT DEPRESSION

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MOKHBER N.; TALAEI ALI

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Journal Paper

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Journal: Iranian Journal of Psychiatry and Behavioral Sciences Year:2008 | Volume:1 | Issue:2 Page(s): 23-27

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Title

COMPARING THE EFFICACY OF ADD-ON NORTRYPTILINE WITH TRIIODOTHYRONINE IN THE MANAGEMENT OF CITALOPRAM-RESISTANT DEPRESSION

Author(s)

MOKHBER N. | TALAEI ALI | Issue Writer Certificate

Keywords

CITALOPRAM

DEPRESSION

NORTRYPTILINE

TRIIODOTHYRONINE

Abstract

Objective: To manage a treatment resistant DEPRESSION, clinicians may add a second medication to the first antidepressant drug. The aim of the current research was to study the outcome of augmentation of CITALOPRAM with NORTRYPTILINE or TRIIODOTHYRONINE in a randomized clinical trial.Methods: We selected 48 adult outpatients with a diagnosis of non-psychotic major depressive disorder who had not responded to 12 weeks CITALOPRAM therapy (40 mg per day). They were randomly allocated to two groups. One group received nortryiptiline (at a dose of up to 150 mg per day) and the other TRIIODOTHYRONINE (T3) (at a dose of up to 50 mg per day). The remission of DEPRESSION was defined as a score of 7 or less on the 17-item Hamilton Rating Scale for DEPRESSION (HRSD-17).Results: After 8 weeks, the nortriptyline group had a higher remission rate (33.33 %) than the TRIIODOTHYRONINE group (17.64%). The nortriptyline group, however, had a higher drop out rate due to experiencing more side effects.Conclusion: Augmentation of CITALOPRAM with NORTRYPTILINE seems to be effective in the management of treatment resistant DEPRESSION. However, one should strike a balance between the efficacy and the tolerability of this approach, as there is a higher chance of experiencing side effects by the patients.

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APA: Copy

MOKHBER, N., & TALAEI, ALI. (2008). COMPARING THE EFFICACY OF ADD-ON NORTRYPTILINE WITH TRIIODOTHYRONINE IN THE MANAGEMENT OF CITALOPRAM-RESISTANT DEPRESSION. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 1(2), 23-27. SID. https://sid.ir/paper/311878/en

Vancouver: Copy

MOKHBER N., TALAEI ALI. COMPARING THE EFFICACY OF ADD-ON NORTRYPTILINE WITH TRIIODOTHYRONINE IN THE MANAGEMENT OF CITALOPRAM-RESISTANT DEPRESSION. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2008;1(2):23-27. Available from: https://sid.ir/paper/311878/en

IEEE: Copy

N. MOKHBER, and ALI TALAEI, “COMPARING THE EFFICACY OF ADD-ON NORTRYPTILINE WITH TRIIODOTHYRONINE IN THE MANAGEMENT OF CITALOPRAM-RESISTANT DEPRESSION,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 1, no. 2, pp. 23–27, 2008, [Online]. Available: https://sid.ir/paper/311878/en

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