DETERMINATION OF P53 PROTEIN, KI67 ANTIGEN AND 
C-ERB-B2 EXPRESSION AND THEIR CORRELATION IN WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA (SCC) OF TONGUE

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JALAYER NADERI N.; TIRGARI F.; GHOLAM ALIPOUR N.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2008 | Volume:15 | Issue:76 Page(s): 1-6

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Title

DETERMINATION OF P53 PROTEIN, KI67 ANTIGEN AND C-ERB-B2 EXPRESSION AND THEIR CORRELATION IN WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA (SCC) OF TONGUE

Author(s)

JALAYER NADERI N. | TIRGARI F. | GHOLAM ALIPOUR N. | Issue Writer Certificate

Keywords

IMMUNOHISTOCHEMISTRYQ3

KI67 ANTIGENQ3

SANS-SERIF">P53 PROTEINQ3

SANS-SERIF"> C-ERB-B2Q2

SQUAMOUS CELL CARCINOMAQ2

TONGUEQ2

Abstract

Introduction: Tumor development is identified by an imbalance between proliferation and apoptosis. The mutation of suppressor genes such as P53 and overexpression of C-erb-B2 as an oncogene are important factors in carcinogenesis. The overexpression of ki67 has been demonstrated in different tumors. Our knowledge about C-erb-B2 and its correlation with cellular proliferation in oral Squamous Cell Carcinoma (SCC) has not been elucidated.Objective: The aim of study was the comparison of Ki67, P53 and C-erb-B2 immunoreactivity in well – differentiated SCC of TONGUE.Materials & Methods: This study was a descriptive. Five sections of well differentiated SCC were prepared and stained by immunohistochemical (IHC) method. IHC slides were examined for Ki67, P53 and C-erb-B2 for positive staining by counting positive cells per 1000 epithelial cells; labeling indexes (LI) were calculated and LI means were achieved. The correlation test was used to compare the results.Results: The mean numbers of Ki67, P53 and C-erb-B2 positive cells were 399.4±42.97, 221.4±330.32 and 26.8±27.22, respectively. The correlation test was shown the positive correlation between Ki67 and P53 (p<0.02, r=91.5%). There was not any positive correlation between Ki67 and C-erb-B2 (p<0.97, r= -1.7%) and also P53 and C-erb-B2 (p<0.8, r= -13%).Conclusion: Immunoreactivities of P53, ki67 and C-erb-B2 were positive in TONGUE well-differentiated SCC. The positive correlation was seen between P53 and ki67 expression.

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APA: Copy

JALAYER NADERI, N., TIRGARI, F., & GHOLAM ALIPOUR, N.. (2008). DETERMINATION OF P₅₃PROTEIN, KI67 ANTIGEN AND C-ERB-B₂EXPRESSION AND THEIR CORRELATION IN WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA (SCC) OF TONGUE. DANESHVAR MEDICINE, 15(76), 1-6. SID. https://sid.ir/paper/31189/en

Vancouver: Copy

JALAYER NADERI N., TIRGARI F., GHOLAM ALIPOUR N.. DETERMINATION OF P₅₃PROTEIN, KI67 ANTIGEN AND C-ERB-B₂EXPRESSION AND THEIR CORRELATION IN WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA (SCC) OF TONGUE. DANESHVAR MEDICINE[Internet]. 2008;15(76):1-6. Available from: https://sid.ir/paper/31189/en

IEEE: Copy

N. JALAYER NADERI, F. TIRGARI, and N. GHOLAM ALIPOUR, “DETERMINATION OF P₅₃PROTEIN, KI67 ANTIGEN AND C-ERB-B₂EXPRESSION AND THEIR CORRELATION IN WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA (SCC) OF TONGUE,” DANESHVAR MEDICINE, vol. 15, no. 76, pp. 1–6, 2008, [Online]. Available: https://sid.ir/paper/31189/en

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