Buprenorphine Added on Brief Cognitive Behavioral Therapy for Treatment of Methamphetamine Use Disorder

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SHARIATIRAD SCHWANN; MAHJOUB ALIREZA; HAQIQI ASHRAF; REZAEI HEMAMI MOHSEN; Tofighi Babak; EKHTIARI HAMED; EFFATPANAH MOHAMMAD

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Journal: Iranian Journal of Psychiatry and Behavioral Sciences Year:2018 | Volume:12 | Issue:2 Page(s): 0-0

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Title

Buprenorphine Added on Brief Cognitive Behavioral Therapy for Treatment of Methamphetamine Use Disorder

Author(s)

Keywords

Buprenorphine

Iran

Methamphetamine

CBT

Abstract

Background: Methamphetamine (MA) use remains a major public health concern around the world. Recent findings suggest that Buprenorphine may be helpful for cocaine use reduction. Moreover, animal studies described reduced dopamine peak effect following MA use, due to the administration of low dose Buprenorphine. Objectives: This study examined the effectiveness of Buprenorphine with brief cognitive behavioral therapy on MA use disorder. Methods: The study was conducted in an outpatient substance abuse treatment center in Qazvin, Iran. Nineteen MA users received Buprenorphine for 24 weeks combined with brief cognitive behavioral therapy in an outpatient substance abuse treatment program, three times per week, as a before and after non-randomization study. Clinical outcomes included treatment retention, MA use, degree of MA dependency and craving, quality of life, cognitive abilities questionnaire, addiction severity and also adverse events. Data was analyzed by performing repeated measures analysis and the Friedman test for nonparametric variables. Results: Fifteen participants completed the study during six months and frequency of MA use was significantly decreased at 24 weeks (P < 0. 001). There were also significant reductions in craving (P < 0. 001), degree of MA dependence (P < 0. 001), and improvements in quality of life, cognitive ability, and some subscales of addiction severity. Conclusions: The results of this preliminary clinical study demonstrated that Buprenorphine could potentially attenuateMAcraving and alternate rewarding effects of MAand had promising effects on cognitive impairment. Furthermore, Buprenorphine can be considered as a harm reduction intervention in some communities, in which the people, as a result of cultural beliefs, do not accept a therapy, which only consists of counseling and no medications.

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APA: Copy

SHARIATIRAD, SCHWANN, MAHJOUB, ALIREZA, HAQIQI, ASHRAF, REZAEI HEMAMI, MOHSEN, Tofighi, Babak, EKHTIARI, HAMED, & EFFATPANAH, MOHAMMAD. (2018). Buprenorphine Added on Brief Cognitive Behavioral Therapy for Treatment of Methamphetamine Use Disorder. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 12(2), 0-0. SID. https://sid.ir/paper/312218/en

Vancouver: Copy

SHARIATIRAD SCHWANN, MAHJOUB ALIREZA, HAQIQI ASHRAF, REZAEI HEMAMI MOHSEN, Tofighi Babak, EKHTIARI HAMED, EFFATPANAH MOHAMMAD. Buprenorphine Added on Brief Cognitive Behavioral Therapy for Treatment of Methamphetamine Use Disorder. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2018;12(2):0-0. Available from: https://sid.ir/paper/312218/en

IEEE: Copy

SCHWANN SHARIATIRAD, ALIREZA MAHJOUB, ASHRAF HAQIQI, MOHSEN REZAEI HEMAMI, Babak Tofighi, HAMED EKHTIARI, and MOHAMMAD EFFATPANAH, “Buprenorphine Added on Brief Cognitive Behavioral Therapy for Treatment of Methamphetamine Use Disorder,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 12, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/312218/en

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