Effectiveness of Transcranial Direct Current Stimulation onWorry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial

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SADEGHI MOVAHED FARIBA; ALIZADEH GORADEL JABER; POURESMALI ASGHAR; MOWLAIE MEHRI

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Journal: Iranian Journal of Psychiatry and Behavioral Sciences Year:2018 | Volume:12 | Issue:2 Page(s): 0-0

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Title

Effectiveness of Transcranial Direct Current Stimulation onWorry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial

Author(s)

SADEGHI MOVAHED FARIBA | ALIZADEH GORADEL JABER | POURESMALI ASGHAR | MOWLAIE MEHRI | Issue Writer Certificate

Keywords

Anxiety

Depression

Generalized Anxiety Disorder

tDCS

Worry

Abstract

Background: Due to low adherence to treatment and side effects of pharmacotherapy, using new brain stimulation, such as transcranial direct current stimulation (tDCS) in patients with Anxiety disorders are available. Objectives: The present researchwasperformed to evaluate theefficacyof tDCSandcompareit with pharmacotherapyonreduction of Worry, Depression, and Anxiety in a group of Iranian patients with generalized Anxiety disorder (GAD). Methods: This study was a quasi-experimental research. A total of 18 patients (46% females and 64% males) withGADwere randomly assigned either to tDCS, pharmacotherapy or sham conditions. Stimulation was delivered over the contralateral deltoid at 2 m/A during 20 minutes in 10 sessions of 4 weeks. Symptoms were assessed by a 7-item GAD scale, HARS, HDRS, and PSWQ in pre-test, post-test and follow up assessment (2 months later). Analysis of variance with repeated measure was used to analyze the data. Results: The results showed that both tDCS and pharmacotherapy were effective in reducing Worry symptoms, also the pharmacotherapy group compared with the tDCS group and sham condition was more effective in treating of Worry. Anxiety symptoms were reduced by both tDCS and pharmacotherapy and the difference between the 2 methods was not significant. Finally, the effectiveness of tDCS therapy on reducing depressive symptoms was more significant than pharmacotherapy. Conclusions: The tDCS is a promising treatment for generalized Anxiety disorder, especially in depressive and Worry symptoms.

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APA: Copy

SADEGHI MOVAHED, FARIBA, ALIZADEH GORADEL, JABER, POURESMALI, ASGHAR, & MOWLAIE, MEHRI. (2018). Effectiveness of Transcranial Direct Current Stimulation onWorry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 12(2), 0-0. SID. https://sid.ir/paper/312230/en

Vancouver: Copy

SADEGHI MOVAHED FARIBA, ALIZADEH GORADEL JABER, POURESMALI ASGHAR, MOWLAIE MEHRI. Effectiveness of Transcranial Direct Current Stimulation onWorry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2018;12(2):0-0. Available from: https://sid.ir/paper/312230/en

IEEE: Copy

FARIBA SADEGHI MOVAHED, JABER ALIZADEH GORADEL, ASGHAR POURESMALI, and MEHRI MOWLAIE, “Effectiveness of Transcranial Direct Current Stimulation onWorry, Anxiety, and Depression in Generalized Anxiety Disorder: A Randomized, Single-Blind Pharmacotherapy and Sham-Controlled Clinical Trial,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 12, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/312230/en

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