THE EFFECT OF HESPERETIN ON SERUM LEVEL OF ASPARTATE AND ALANINE AMOINOTRANSFERASE AND HEPATIC AND CARDIAC LEVEL OF MALONDIALDEHYDE IN DIABETIC RATS

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NARENJKAR J.; ROGHANI MEHRDAD; SHEKOUHI MAHDI

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2010 | Volume:18 | Issue:89 Page(s): 33-42

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Title

THE EFFECT OF HESPERETIN ON SERUM LEVEL OF ASPARTATE AND ALANINE AMOINOTRANSFERASE AND HEPATIC AND CARDIAC LEVEL OF MALONDIALDEHYDE IN DIABETIC RATS

Author(s)

NARENJKAR J. | ROGHANI MEHRDAD | SHEKOUHI MAHDI | Issue Writer Certificate

Keywords

HESPERETINQ3

DIABETES MELLITUSQ3

AMINOTRANSFERASEQ2

MALONDIALDEHYDEQ2

Abstract

Background and Objective: DIABETES MELLITUS accompanies increased MALONDIALDEHYDE as a marker of oxidative stress and increased serum level of aspartate and alanine aminotranferase due to tissue damage. Due to antidiabetic effect of HESPERETIN, this study was done to evaluate its effect on level of these factors in diabetes.Materials and Methods: Male rats (n = 32) were divided into control, treated control, diabetic, and treated diabetic groups. For induction of diabetes, streptozotocin at a dose of 60 mg/kg (i.p) was injected. HESPERETIN was administered at a dose of 10 mg/kg/day for 4 weeks one week post-experiment. Serum levels of aspartate and alanine aminotranferase were measured before the study and at the end of the study. In addition, level of MALONDIALDEHYDE (MDA) was measured in liver and heart tissues.Results: A significant increase in serum level of aspartate and alanine aminotranferase (p<0.05-0.01) was observed in diabetic rats and HESPERETIN treatment significantly reduced only serum level of alanine AMINOTRANSFERASE (p<0.05). In addition, diabetes was followed by increased level of MDA in liver and heart tissues (p<0.01) and HESPERETIN treatment significantly reduced MDA level in these tissues (p<0.05).Conclusion: Treatment with HESPERETIN could attenuate serum level of alanine aminotranferase and oxidative stress in hepatic and cardiac tissues, as indicated by a lower tissue level of MDA.

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APA: Copy

NARENJKAR, J., ROGHANI, MEHRDAD, & SHEKOUHI, MAHDI. (2010). THE EFFECT OF HESPERETIN ON SERUM LEVEL OF ASPARTATE AND ALANINE AMOINOTRANSFERASE AND HEPATIC AND CARDIAC LEVEL OF MALONDIALDEHYDE IN DIABETIC RATS. DANESHVAR MEDICINE, 18(89), 33-42. SID. https://sid.ir/paper/31224/en

Vancouver: Copy

NARENJKAR J., ROGHANI MEHRDAD, SHEKOUHI MAHDI. THE EFFECT OF HESPERETIN ON SERUM LEVEL OF ASPARTATE AND ALANINE AMOINOTRANSFERASE AND HEPATIC AND CARDIAC LEVEL OF MALONDIALDEHYDE IN DIABETIC RATS. DANESHVAR MEDICINE[Internet]. 2010;18(89):33-42. Available from: https://sid.ir/paper/31224/en

IEEE: Copy

J. NARENJKAR, MEHRDAD ROGHANI, and MAHDI SHEKOUHI, “THE EFFECT OF HESPERETIN ON SERUM LEVEL OF ASPARTATE AND ALANINE AMOINOTRANSFERASE AND HEPATIC AND CARDIAC LEVEL OF MALONDIALDEHYDE IN DIABETIC RATS,” DANESHVAR MEDICINE, vol. 18, no. 89, pp. 33–42, 2010, [Online]. Available: https://sid.ir/paper/31224/en

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