Prazosin for Trauma Nightmares and Sleep Disturbances in Combat Veterans with Post-Traumatic Stress Disorder

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KHAZAIE HABIBOLAH; NASOURI MARZIE; GHADAMI MOHAMMAD RASOUL

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Journal Paper

Paper Information

Journal: Iranian Journal of Psychiatry and Behavioral Sciences Year:2016 | Volume:10 | Issue:3 Page(s): 1-6

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Information Journal Paper

Title

Prazosin for Trauma Nightmares and Sleep Disturbances in Combat Veterans with Post-Traumatic Stress Disorder

Author(s)

KHAZAIE HABIBOLAH | NASOURI MARZIE | GHADAMI MOHAMMAD RASOUL | Issue Writer Certificate

Keywords

Nightmare

Post-Traumatic Stress Disorder

Prazosin

Sleep Disturbance

Abstract

Background: Prazosin is significantly effective to reduce Sleep Disturbance and trauma Nightmare in patients with Post-Traumatic Stress Disorder (PTSD); however, results of different studies were evaluated. Objectives: The currentrandomized clinical trialaimedto assess the effects of Prazosinonsleep parametersandNightmaresamong veterans with chronic PTSD. Materials and Methods: Thirty-two veterans with chronic war-induced PTSD and distressing Nightmares were randomized into Prazosin and placebo groups for eight weeks. The main symptoms were qualified using the recurrent distressing dreams item of the clinician administered PTSD scale (CAPS) and the daytime symptom severity was measured by PTSD checklist (PCL) and the objective sleep quality assessment by actigraphy. Results: Compared with placebo, Prazosin had no significant effects on reduction of daytime symptoms (P = 0. 69) and frequency and intensity of trauma-related Nightmares. Also, there were no significant differences between pre-and post-treatment actigraphy measurements (P > 0. 05). Conclusions: The study findings showed that Prazosin had no significant effect on reduction of PTSD symptoms as well as Nightmares among veterans with chronic PTSD. Further clinical trials are needed to define the effect of Prazosin on sleep physiology and whether such effects regarding the therapeutic response.

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APA: Copy

KHAZAIE, HABIBOLAH, NASOURI, MARZIE, & GHADAMI, MOHAMMAD RASOUL. (2016). Prazosin for Trauma Nightmares and Sleep Disturbances in Combat Veterans with Post-Traumatic Stress Disorder. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 10(3), 1-6. SID. https://sid.ir/paper/312379/en

Vancouver: Copy

KHAZAIE HABIBOLAH, NASOURI MARZIE, GHADAMI MOHAMMAD RASOUL. Prazosin for Trauma Nightmares and Sleep Disturbances in Combat Veterans with Post-Traumatic Stress Disorder. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2016;10(3):1-6. Available from: https://sid.ir/paper/312379/en

IEEE: Copy

HABIBOLAH KHAZAIE, MARZIE NASOURI, and MOHAMMAD RASOUL GHADAMI, “Prazosin for Trauma Nightmares and Sleep Disturbances in Combat Veterans with Post-Traumatic Stress Disorder,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 10, no. 3, pp. 1–6, 2016, [Online]. Available: https://sid.ir/paper/312379/en

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