مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

DETECTION OF SOMATIC MUTATION OF CODON 248 OF P53 GENE BETWEEN IRANIAN WOMEN WITH BREAST CANCER

Pages

  27-32

Abstract

 Objective: Detection of P53 gene MUTATION on its CODON 248 between Iranian women with BREAST CANCER by PCR-RFLP.Material and methods: DNA extraction of tumor tissues was performed in 53 patients with primary BREAST CANCER. Designing primer for the sub-studying codon was performed with NTI-Vector software and detection of CODON 248 MUTATION was done by Msp I PCR_RFLP.Results: The somatic MUTATIONs of P53 on CODON 248 were observed in 11.3% (6 of 53) of our cases, in which 9.4% were heterozygote MUTATION and the rest were homozygote MUTATION. This ratio is the highest reported percentage in the world. Conclusion: This perusal indicates genotyping of P53 gene on CODON 248 is important for Iranian women with BREAST CANCER risk factors.

Cites

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  • Cite

    APA: Copy

    SHOJAEI, NASRIN, & TIRGARI, F.. (2008). DETECTION OF SOMATIC MUTATION OF CODON 248 OF P53 GENE BETWEEN IRANIAN WOMEN WITH BREAST CANCER. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 1(1), 27-32. SID. https://sid.ir/paper/312432/en

    Vancouver: Copy

    SHOJAEI NASRIN, TIRGARI F.. DETECTION OF SOMATIC MUTATION OF CODON 248 OF P53 GENE BETWEEN IRANIAN WOMEN WITH BREAST CANCER. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2008;1(1):27-32. Available from: https://sid.ir/paper/312432/en

    IEEE: Copy

    NASRIN SHOJAEI, and F. TIRGARI, “DETECTION OF SOMATIC MUTATION OF CODON 248 OF P53 GENE BETWEEN IRANIAN WOMEN WITH BREAST CANCER,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 1, no. 1, pp. 27–32, 2008, [Online]. Available: https://sid.ir/paper/312432/en

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