STUDY OF TWO COMMON P53 GENE MUTATIONS IN GASTRIC CANCER USING PCR-RFLP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, IRAN, 2003

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAFAARI CHALESHTORI J.; MORADI M.T.; FAROKHI EFAT; TABATABAEIFAR M.A.; TAHERZADEH FAROKHSHAHRI MARYAM; SHAYESTEH F.; MOBINI GH.R.; BANI TALEBI M.; KHADEMI S.; MARDANI G.; SHAHRANI M.; PARVIN NEDA; SHAHINFARD N.; RAHIMIAN GH.A.; NAZEM H.A.; HASHEMZADEH CHALESHTORI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2009 | Volume:10 | Issue:4 Page(s): 43-50

Download Full-Text

Persian Verion

View:

2,626

Download:

Cites:

Information Journal Paper

Title

STUDY OF TWO COMMON P53 GENE MUTATIONS IN GASTRIC CANCER USING PCR-RFLP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, IRAN, 2003

Author(s)

Keywords

P53 GENEQ3

PCR- RFLPQ3

GASTRIC CANCERQ2

Abstract

Background and aim: GASTRIC CANCER is the most common cause of cancer death world wide after lung cancer. Genetic factors including oncogenes and tumor suppressor genes are always involved in progression of this cancer. The P53 tumor suppressor gene is believed to have a broad role in the cell such as programmed cell death and stop cell replicating damaged DNA which has been summarized as the guardian of the genome. This study aims to determine the frequency of two common P53 GENE mutations using PCR-RFLP in GASTRIC CANCER in Chaharmahal va Bakhtiari province. Methods: This descriptive – lab based study describes the mutation analysis of paraffin embedded gastric samples from 38 patients in Chaharmahal va Bakhtiari province. We have investigated the frequency of P53 GENE mutation in exons 7 and 8 by PCR-RFLP to detect alteration in two common hot spots in codon 248 and 282. Results: We determined no mutation in P53 GENE hot spots in codon 248 and 282. Conclusion: We conclude that association of P53 GENE mutations with GASTRIC CANCER is very low in Chaharmahal va Bakhtiari province. However we have examined only 38 gastric samples and more samples need to be investigated to reveal the contribution of P53 GENE mutation in causing GASTRIC CANCER in this province. Also it is necessary to study the entire coding region and promoter of the gene in patients from different population and ethnic groups.

Cites

FEEDING BEHAVIOR ASSOCIATED WITH GASTRIC CANCER

References

Cite

APA: Copy

SAFAARI CHALESHTORI, J., MORADI, M.T., FAROKHI, EFAT, TABATABAEIFAR, M.A., TAHERZADEH FAROKHSHAHRI, MARYAM, SHAYESTEH, F., MOBINI, GH.R., BANI TALEBI, M., KHADEMI, S., MARDANI, G., SHAHRANI, M., PARVIN, NEDA, SHAHINFARD, N., RAHIMIAN, GH.A., NAZEM, H.A., & HASHEMZADEH CHALESHTORI, M.. (2009). STUDY OF TWO COMMON P53 GENE MUTATIONS IN GASTRIC CANCER USING PCR-RFLP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, IRAN, 2003. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 10(4), 43-50. SID. https://sid.ir/paper/58455/en

Vancouver: Copy

SAFAARI CHALESHTORI J., MORADI M.T., FAROKHI EFAT, TABATABAEIFAR M.A., TAHERZADEH FAROKHSHAHRI MARYAM, SHAYESTEH F., MOBINI GH.R., BANI TALEBI M., KHADEMI S., MARDANI G., SHAHRANI M., PARVIN NEDA, SHAHINFARD N., RAHIMIAN GH.A., NAZEM H.A., HASHEMZADEH CHALESHTORI M.. STUDY OF TWO COMMON P53 GENE MUTATIONS IN GASTRIC CANCER USING PCR-RFLP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, IRAN, 2003. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;10(4):43-50. Available from: https://sid.ir/paper/58455/en

IEEE: Copy

J. SAFAARI CHALESHTORI, M.T. MORADI, EFAT FAROKHI, M.A. TABATABAEIFAR, MARYAM TAHERZADEH FAROKHSHAHRI, F. SHAYESTEH, GH.R. MOBINI, M. BANI TALEBI, S. KHADEMI, G. MARDANI, M. SHAHRANI, NEDA PARVIN, N. SHAHINFARD, GH.A. RAHIMIAN, H.A. NAZEM, and M. HASHEMZADEH CHALESHTORI, “STUDY OF TWO COMMON P53 GENE MUTATIONS IN GASTRIC CANCER USING PCR-RFLP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, IRAN, 2003,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 4, pp. 43–50, 2009, [Online]. Available: https://sid.ir/paper/58455/en

Related Journal Papers