مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

THE STUDY OF DNA METHYLATION OF BAX GENE PROMOTER IN BREAST AND COLORECTAL CARCINOMA CELL LINES

Pages

  59-64

Keywords

POLYMERASE CHAIN REACTION (PCR) 

Abstract

 Background: The Bcl-2 protein family members have known as essential controllers of mitochondrial pathway of apoptosis. Bax is a proapoptotic member of Bcl-2 protein family, which is well known to play crucial roles for apoptosis control.bax has been implicated as potential tumor suppressor in certain solid tumors such as breast and colorectal carcinoma. DNA methylation of promoter associated CPG ISLANDs has known as a common mechanism for gene inactivation in tumor cells.Methods: The Methylation Specific PCR (MSP) has used to find the methylation profile of the bax gene promoter CPG ISLANDs in colorectal and BREAST CANCER cell lines.Results: We have not detected any kind of "CPG ISLANDs hyper methylation" in promoter region of the bax gene in T47D, MCF7 (as ER positive), MDA-MB-231 and MDA-MB-468 (as ER negative) breast carcinoma-derived cell lines and COLORECTAL CANCER cell lines H29 and Caco II.Conclusion: It seems that CPG ISLAND methylation could not play the main role in down-regulation of bax gene in breast and colon cancers.

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    APA: Copy

    ALIPOUR, MOHSEN, ZARGAR, SEYED JALAL, SAFARIAN, SHAHROKH, FOULADDEL, SHAMILEH, AZIZI, EBRAHIM, & JAFARGHOLIZADEH, NASER. (2013). THE STUDY OF DNA METHYLATION OF BAX GENE PROMOTER IN BREAST AND COLORECTAL CARCINOMA CELL LINES. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 6(2), 59-64. SID. https://sid.ir/paper/312581/en

    Vancouver: Copy

    ALIPOUR MOHSEN, ZARGAR SEYED JALAL, SAFARIAN SHAHROKH, FOULADDEL SHAMILEH, AZIZI EBRAHIM, JAFARGHOLIZADEH NASER. THE STUDY OF DNA METHYLATION OF BAX GENE PROMOTER IN BREAST AND COLORECTAL CARCINOMA CELL LINES. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2013;6(2):59-64. Available from: https://sid.ir/paper/312581/en

    IEEE: Copy

    MOHSEN ALIPOUR, SEYED JALAL ZARGAR, SHAHROKH SAFARIAN, SHAMILEH FOULADDEL, EBRAHIM AZIZI, and NASER JAFARGHOLIZADEH, “THE STUDY OF DNA METHYLATION OF BAX GENE PROMOTER IN BREAST AND COLORECTAL CARCINOMA CELL LINES,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 6, no. 2, pp. 59–64, 2013, [Online]. Available: https://sid.ir/paper/312581/en

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