THE EFFECT OF INTERLEUKIN 36 GENE THERAPY IN THE REGRESSION OF TUMOR

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SOLAHAYE KAHNAMOUII SHIVA; FARHADI FARROKH; RAHKARE FARSHI MAHNI; PAKDEL FARZANEH; KASHEFIMEHR ATABAK; POURALIBABA FIROUZ; SHIRANI GHOLAMREZA; BAYAT MOHAMMAD; KARIMI ABBAS

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Journal Paper

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Journal: International Journal of Cancer Management Year:2014 | Volume:7 | Issue:4 Page(s): 197-203

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Title

THE EFFECT OF INTERLEUKIN 36 GENE THERAPY IN THE REGRESSION OF TUMOR

Author(s)

Keywords

IL-36

GENE THERAPY

TUMOR MASS

ELISA

IMMUNOBLOTING

Abstract

Background: Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors and is one of the cancer treatment strategies. Recently, interluekin36 (IL36) has been used as immunotherapeutic agents in cancer GENE THERAPY. Present study investigated that the IL36 GENE THERAPY effects on the regression of TUMOR MASSes in mouse model. Aim of this study is determination of the GENE THERAPY effects by IL36 in the regression of TUMOR MASSes in mouse model.Methods: To study the therapeutic efficacy of this cytokine, WEHI-164 tumor cells were transected with mIL36 plasmids. ELISA test was used to check cytokine production by transected cells. To establish fibro sarcoma mouse model, Tumoral transfected cells were injected subcutaneously to inoculate tumor in BALB/C mice. Tumor volumes were measured by caliper. Mice were sacrificed and tumors were extracted. The expression of IL36 and IFN-γ was studied with Real-time PCR and immunoblotting. The expression of Ki-67 (a tumor proliferation marker) in TUMOR MASSes was studied by immunohistochemistry staining. In this study we had 2 groups which are treated with IL-36 and Untreated with IL-36 as a blank. Results: The group treated with IL36 indicated decrease of TUMOR MASS volume (p<0.001). The results of western blotting and real-time PCR showed the IL36 expression increased in the group treated with IL36 (with relative expression of 1.9).Conclusion: Immunohistochemistry staining indicated that the Ki-67expression has been reduced in the group interfered with IL36. IL36 GENE THERAPY has therapeutic effects on the regression of TUMOR MASSes in fibro sarcoma mouse model.

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APA: Copy

SOLAHAYE KAHNAMOUII, SHIVA, FARHADI, FARROKH, RAHKARE FARSHI, MAHNI, PAKDEL, FARZANEH, KASHEFIMEHR, ATABAK, POURALIBABA, FIROUZ, SHIRANI, GHOLAMREZA, BAYAT, MOHAMMAD, & KARIMI, ABBAS. (2014). THE EFFECT OF INTERLEUKIN 36 GENE THERAPY IN THE REGRESSION OF TUMOR. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 7(4), 197-203. SID. https://sid.ir/paper/312635/en

Vancouver: Copy

SOLAHAYE KAHNAMOUII SHIVA, FARHADI FARROKH, RAHKARE FARSHI MAHNI, PAKDEL FARZANEH, KASHEFIMEHR ATABAK, POURALIBABA FIROUZ, SHIRANI GHOLAMREZA, BAYAT MOHAMMAD, KARIMI ABBAS. THE EFFECT OF INTERLEUKIN 36 GENE THERAPY IN THE REGRESSION OF TUMOR. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2014;7(4):197-203. Available from: https://sid.ir/paper/312635/en

IEEE: Copy

SHIVA SOLAHAYE KAHNAMOUII, FARROKH FARHADI, MAHNI RAHKARE FARSHI, FARZANEH PAKDEL, ATABAK KASHEFIMEHR, FIROUZ POURALIBABA, GHOLAMREZA SHIRANI, MOHAMMAD BAYAT, and ABBAS KARIMI, “THE EFFECT OF INTERLEUKIN 36 GENE THERAPY IN THE REGRESSION OF TUMOR,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 7, no. 4, pp. 197–203, 2014, [Online]. Available: https://sid.ir/paper/312635/en

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