The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response

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KHOSRAVI MOHAMMAD; Mayahi Mansour; Kaviani Farnoosh; NEMATI MOHAMMAD

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Journal Paper

Paper Information

Journal: JOURNAL OF ARTHROPOD-BORNE DISEASES Year:2017 | Volume:11 | Issue:4 Page(s): 497-503

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Title

The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response

Author(s)

KHOSRAVI MOHAMMAD | Mayahi Mansour | Kaviani Farnoosh | NEMATI MOHAMMAD | Issue Writer Certificate

Keywords

Venom

Mesobuthus eupeus

Immune response

Abstract

Background: Many elements such as immunosuppressive, chemotactic and anti-inflammatory peptide that could effect on human and animals physiologic system were determined in Venom. This study evaluated the use of Meso-buthus eupeus scorpion Venom fractions as an immunomodulator. Methods: The Venom fractions collected from Khuzestan Province in South West of Iran were purified by ion ex-change chromatography. Elution of the bounded elements was done by using a linear gradient of sodium chloride (0. 1, 0. 25, 0. 5, 0. 75, 1, 1. 25, 1. 5 and 2 molar). The fractions were analyzed by Bradford spectrophotometric and SDS-PAGE method. After treatments of chicken with Venom fractions and sheep red blood cell (SRBC), direct hae-magglutination test in microtiter plate was used for the determination of the chicken SRBC antibody titer. Results: The fraction released by NaCl 1. 25M had the highest protein concentration. The highest and lowest anti-body titer was determined at the fifth (NaCl 0. 75 molar) and seventh fraction (NaCl 1. 25 molar), respectively. Conclusion: Different protein profile of isolated fractions, were associated with various effect on Immune response. Both enhancing and suppressing of the chicken humoral Immune response to SRBC were observed after M. eupeus faction’ s Venom treatment. It is due to biological functions of Venom components. Purification of these elements would provide the new agents for Immune responses manipulation.

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APA: Copy

KHOSRAVI, MOHAMMAD, Mayahi, Mansour, Kaviani, Farnoosh, & NEMATI, MOHAMMAD. (2017). The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response. JOURNAL OF ARTHROPOD-BORNE DISEASES, 11(4), 497-503. SID. https://sid.ir/paper/312943/en

Vancouver: Copy

KHOSRAVI MOHAMMAD, Mayahi Mansour, Kaviani Farnoosh, NEMATI MOHAMMAD. The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response. JOURNAL OF ARTHROPOD-BORNE DISEASES[Internet]. 2017;11(4):497-503. Available from: https://sid.ir/paper/312943/en

IEEE: Copy

MOHAMMAD KHOSRAVI, Mansour Mayahi, Farnoosh Kaviani, and MOHAMMAD NEMATI, “The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response,” JOURNAL OF ARTHROPOD-BORNE DISEASES, vol. 11, no. 4, pp. 497–503, 2017, [Online]. Available: https://sid.ir/paper/312943/en

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