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Information Journal Paper

Title

Antiplasmodial Property of Glycyrrhiza glabra Traditionally Used for Malaria in Iran: Promising Activity with High Selectivity Index for Malaria

Pages

  135-140

Abstract

 Background: Development of resistance against the frontline anti-Malarial drugs has created an alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-Malarial agents. The aim of this study was to assess antiplasmodial activity of the different fractions of root extract of Glycyr-rhiza glabra. Methods: Roots of G. glabra were collected from Tarom district of Zanjan Province in 2016 and then dried root ma-terial was chopped and consecutively extracted by the percolation method using solvents of different polarity. Result-ing extracts were assessed for in vitro and in vivo anti-Malarial and cell cytotoxicity activities. Results: Among the three different solvent fractions studied, water-methanol and ethyl acetate fractions showed promising in vitro antiplasmodial activity against CQ-sensitive Plasmodium falciparum 3D7 strain (IC50= 9. 95 and 13μ g/ml, respectively). Further, the selectivity indices (HeLa cells versus P. falciparum) for the promising water-methanol fraction showed selectivity for P. falciparum and potential safer therapy for human. Interestingly, water-methanol and ethyl acetate fractions showed a significant suppression of parasite growth (72. 2% and 65%, respec-tively) in comparison with control group in mice infected with P. berghei (P< 0. 05). Conclusion: The promising antiplasmodial activity of the aqueous fraction of G. glabra obtained in our study war-rant bioassay-guided fractionation of this fraction to identify active principles responsible for antiplasmodial activity.

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    APA: Copy

    RAMAZANI, ALI, TAVAKOLIZADEH, MAHDI, Ramazani, Samira, KHEIRI MANJILI, HAMIDREZA, & ESKANDARI, MEHDI. (2018). Antiplasmodial Property of Glycyrrhiza glabra Traditionally Used for Malaria in Iran: Promising Activity with High Selectivity Index for Malaria. JOURNAL OF ARTHROPOD-BORNE DISEASES, 12(2), 135-140. SID. https://sid.ir/paper/313007/en

    Vancouver: Copy

    RAMAZANI ALI, TAVAKOLIZADEH MAHDI, Ramazani Samira, KHEIRI MANJILI HAMIDREZA, ESKANDARI MEHDI. Antiplasmodial Property of Glycyrrhiza glabra Traditionally Used for Malaria in Iran: Promising Activity with High Selectivity Index for Malaria. JOURNAL OF ARTHROPOD-BORNE DISEASES[Internet]. 2018;12(2):135-140. Available from: https://sid.ir/paper/313007/en

    IEEE: Copy

    ALI RAMAZANI, MAHDI TAVAKOLIZADEH, Samira Ramazani, HAMIDREZA KHEIRI MANJILI, and MEHDI ESKANDARI, “Antiplasmodial Property of Glycyrrhiza glabra Traditionally Used for Malaria in Iran: Promising Activity with High Selectivity Index for Malaria,” JOURNAL OF ARTHROPOD-BORNE DISEASES, vol. 12, no. 2, pp. 135–140, 2018, [Online]. Available: https://sid.ir/paper/313007/en

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