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Information Journal Paper

Title

MINOR HISTOCOMPATIBILITY ANTIGEN HA-1 FREQUENCY AND ACUTE GVHD IN SOME HEMATOPOIETIC STEM SELL TRANSPLANTED IRANIAN PATIENTS

Pages

  33-38

Keywords

HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) 

Abstract

 Background: It is suggested that HA-1 mismatching among hematopoietic stem cell transplanted recipients‐donors is associated with acute graft-versus-host disease (aGVHD). So the aim of this study was to evaluate HA-1 frequency and examine the correlation between HA-1 disparity and GVHD patients who received transplantation from a HLAidentical sibling.Samples and Methods: the DNA was extracted from 30 pairs of HLA-A2-positive IRANIAN recipients-donors with GVHD I-IV and 25 pairs without GVHD. All the patients received HSCT from HLA-identical siblings. HA-1 was detected by SSP-PCR method. The HA-1 typing was performed using SSP method (SSP Minor Histocompatibility Antigen primer sets).Results: The frequency of HA-1R and HA-1H alleles in patients were 0.55 and 0.45 respectively, and showed no significant difference with these alleles frequency in donors 0.53 and 0.47 respectively (p>0.05). The HA-1 disparity was detected in 8 out of 55 donor/recipient pairs (14.5%). The aGVHD (grades I-IV) occurred in 6 (75%) out of 8 patients but in spite of higher incidence of it in the group of patients with HA-1 incompatibility, it was not statistically significant.Conclusion: In spite of higher frequency of HA-1 disparity in GVHD+ group our data did not reflect a significant association between the HA-1 disparity and risk of acute GVHD.

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    APA: Copy

    MOHAMMADI, S., SHAIGAN, MOZHGAN, MOGHADAM, K.A., BABAEI, G.R., SAMIEI, S., GHAVAMZADEH, ARDESHIR, & SHAKERPOUR, F.. (2008). MINOR HISTOCOMPATIBILITY ANTIGEN HA-1 FREQUENCY AND ACUTE GVHD IN SOME HEMATOPOIETIC STEM SELL TRANSPLANTED IRANIAN PATIENTS. IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC), 1(1), 33-38. SID. https://sid.ir/paper/313121/en

    Vancouver: Copy

    MOHAMMADI S., SHAIGAN MOZHGAN, MOGHADAM K.A., BABAEI G.R., SAMIEI S., GHAVAMZADEH ARDESHIR, SHAKERPOUR F.. MINOR HISTOCOMPATIBILITY ANTIGEN HA-1 FREQUENCY AND ACUTE GVHD IN SOME HEMATOPOIETIC STEM SELL TRANSPLANTED IRANIAN PATIENTS. IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC)[Internet]. 2008;1(1):33-38. Available from: https://sid.ir/paper/313121/en

    IEEE: Copy

    S. MOHAMMADI, MOZHGAN SHAIGAN, K.A. MOGHADAM, G.R. BABAEI, S. SAMIEI, ARDESHIR GHAVAMZADEH, and F. SHAKERPOUR, “MINOR HISTOCOMPATIBILITY ANTIGEN HA-1 FREQUENCY AND ACUTE GVHD IN SOME HEMATOPOIETIC STEM SELL TRANSPLANTED IRANIAN PATIENTS,” IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC), vol. 1, no. 1, pp. 33–38, 2008, [Online]. Available: https://sid.ir/paper/313121/en

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