مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THALIDOMIDE IS MORE EFFICIENT THAN SODIUM BUTYRATE IN ENHANCING GATA-1 AND EKLF GENE EXPRESSION IN ERYTHROID PROGENITORS DERIVED FROM HSCS WITH β-GLOBIN GENE MUTATION

Pages

  37-41

Abstract

 Background: Efficient induction of fetal hemoglobin (HbF) is considered as an effective therapeutic approach in beta thalassemia. HbF inducer agents can induce the expression of γ-globin gene and produce high levels of HbF via different epigenetic and molecular mechanisms. Thalidomide and sodium butyrate are known as HbF inducer drugs. Material and methods: CD133+ stem cells were isolated from umbilical cord blood of a newborn with minor b-thalassemia in order to evaluate the effects of these two drugs on the in vitro expression of GATA-1 and EKLF genes as erythroid transcription factors. CD133+ stem cells were expanded and differentiated into erythroid lineage and then treated with thalidomide and sodium butyrate and finally analyzed by quantitative real-time PCR. Statistical analysis was performed using student’s t-test by SPSS software. Results: Thalidomide and sodium butyrate increased GATA-1 and EKLF gene expression, compared to the non-treated control (P<0.05). Conclusion: Thalidomide was more efficient than sodium butyrate in augmenting expression of GATA-1 and EKLF genes. It seems that GATA-1 and EKLF have crucial roles in the efficient induction of HbF by thalidomide.

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    APA: Copy

    JALALI FAR, MOHAMMAD ALI, DEHGHANI FARD, ALI, HAJIZAMANI, SAIEDEH, MOSSAHEBI MOHAMMADI, MAJID, YAGHOOTI, HAMID, & SAKI, NAJMALDIN. (2016). THALIDOMIDE IS MORE EFFICIENT THAN SODIUM BUTYRATE IN ENHANCING GATA-1 AND EKLF GENE EXPRESSION IN ERYTHROID PROGENITORS DERIVED FROM HSCS WITH β-GLOBIN GENE MUTATION. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), 10(1), 37-41. SID. https://sid.ir/paper/313426/en

    Vancouver: Copy

    JALALI FAR MOHAMMAD ALI, DEHGHANI FARD ALI, HAJIZAMANI SAIEDEH, MOSSAHEBI MOHAMMADI MAJID, YAGHOOTI HAMID, SAKI NAJMALDIN. THALIDOMIDE IS MORE EFFICIENT THAN SODIUM BUTYRATE IN ENHANCING GATA-1 AND EKLF GENE EXPRESSION IN ERYTHROID PROGENITORS DERIVED FROM HSCS WITH β-GLOBIN GENE MUTATION. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)[Internet]. 2016;10(1):37-41. Available from: https://sid.ir/paper/313426/en

    IEEE: Copy

    MOHAMMAD ALI JALALI FAR, ALI DEHGHANI FARD, SAIEDEH HAJIZAMANI, MAJID MOSSAHEBI MOHAMMADI, HAMID YAGHOOTI, and NAJMALDIN SAKI, “THALIDOMIDE IS MORE EFFICIENT THAN SODIUM BUTYRATE IN ENHANCING GATA-1 AND EKLF GENE EXPRESSION IN ERYTHROID PROGENITORS DERIVED FROM HSCS WITH β-GLOBIN GENE MUTATION,” INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), vol. 10, no. 1, pp. 37–41, 2016, [Online]. Available: https://sid.ir/paper/313426/en

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