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Information Journal Paper

Title

TEN-YEAR EXPERIENCE OF RHINOCEREBRAL ZYGOMYCOSIS IN A TEACHING HOSPITAL IN TEHRAN

Pages

  117-120

Abstract

 Background: RHINOCEREBRAL ZYGOMYCOSIS is a rare, rapidly progressive and often fatal fungal infection occurring in several immunocompromised states. Prior investigators have reported an increasing incidence among Iranian population; therefore, we decided to present the clinical features and TREATMENT outcome of a group of patients with RHINOCEREBRAL ZYGOMYCOSIS.Patients and methods: Medical records of all cases with the diagnosis of RHINOCEREBRAL ZYGOMYCOSIS attending Rasoule-Akram Hospital, Tehran, Iran, were retrospectively reviewed from 1997 to 2007. Age, gender, predisposing illness, surgical procedures, and TREATMENT outcomes were reviewed.Results: Totally, 30 patients (17 males and 13 females) were reviewed with a mean age of 49.4±20.3 years. The lag time between onset of symptoms referable to zygomycosis and commencement of amphotericin B was 1 to 90 days with median of 10 days. An association between delayed TREATMENT and mortality was found (p=0.01). Visual loss was observed in 53.3%. The ethmoid (86.6%) and maxillary sinuses (66.6%) were most commonly involved. Eighteen patients had underlying DIABETES MELLITUS (60%). All patients received medical TREATMENT, while 28 (93.3%) underwent surgical intervention. Twenty three patients (76.7%) had orbital involvement with a mortality rate of 43.5%. The overall mortality rate was 40% (12 cases). Patients with higher doses of amphotericin B and multiple surgical intervention had lower mortality rate (p=0.00 and p=0.01, respectively). Factors such as age, gender, predisposing diseases, orbital involvement, multi-sinus involvement, and white blood cell count had no impact on survival rate.Conclusion: Institution of aggressive surgical debridement of devitalized tissue and the timely initiation of systemic medical therapy is critical for good outcome.

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    APA: Copy

    BARATI, MITRA, TALEBI TAHER, MAHSHID, NOJOMI, MARZIEH, & KERAMI, FATEMEH. (2010). TEN-YEAR EXPERIENCE OF RHINOCEREBRAL ZYGOMYCOSIS IN A TEACHING HOSPITAL IN TEHRAN. IRANIAN JOURNAL OF CLINICAL INFECTIOUS DISEASES, 5(3), 117-120. SID. https://sid.ir/paper/313679/en

    Vancouver: Copy

    BARATI MITRA, TALEBI TAHER MAHSHID, NOJOMI MARZIEH, KERAMI FATEMEH. TEN-YEAR EXPERIENCE OF RHINOCEREBRAL ZYGOMYCOSIS IN A TEACHING HOSPITAL IN TEHRAN. IRANIAN JOURNAL OF CLINICAL INFECTIOUS DISEASES[Internet]. 2010;5(3):117-120. Available from: https://sid.ir/paper/313679/en

    IEEE: Copy

    MITRA BARATI, MAHSHID TALEBI TAHER, MARZIEH NOJOMI, and FATEMEH KERAMI, “TEN-YEAR EXPERIENCE OF RHINOCEREBRAL ZYGOMYCOSIS IN A TEACHING HOSPITAL IN TEHRAN,” IRANIAN JOURNAL OF CLINICAL INFECTIOUS DISEASES, vol. 5, no. 3, pp. 117–120, 2010, [Online]. Available: https://sid.ir/paper/313679/en

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