A RANDOMIZED CONTROLLED TRIAL OF 5-DAY REGIMEN OF AZITHROMYCIN AND A 10-DAY REGIMEN OF CO-AMOXICLAV FOR TREATMENT OF ACUTE SINUSITIS

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RASTEGAR LARI ABDOLAZIZ; GHAFFARIYEH ALIREZA; ETESAM NOUSHIN; MOSTAFAVI HAMID; ALAGHEHBANDAN REZA

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Journal: IRANIAN JOURNAL OF CLINICAL INFECTIOUS DISEASES Year:2010 | Volume:5 | Issue:3 Page(s): 137-141

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Title

A RANDOMIZED CONTROLLED TRIAL OF 5-DAY REGIMEN OF AZITHROMYCIN AND A 10-DAY REGIMEN OF CO-AMOXICLAV FOR TREATMENT OF ACUTE SINUSITIS

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Keywords

ACUTE SINUSITIS

AZITHROMYCIN

CO-AMOXICLAV

Abstract

Background: ACUTE SINUSITIS constitutes a significant portion of health service utilization globally both in- and outpatient as well as emergency department visits, with 83% resulting in a prescription for an antibiotic. This study compared the efficacy of a 5-day regimen of AZITHROMYCIN (a macrolid antibiotic) with a 10-day regimen of coamoxiclav (combination of an amino penicillin with a beta lactamase inhibitor) for the treatment of ACUTE SINUSITIS.Patients and methods: A total of 76 subjects with ACUTE SINUSITIS were randomly assigned in two groups, AZITHROMYCIN (n=40) and CO-AMOXICLAV (n=36). One group received AZITHROMYCIN, 500mg in the first day and 250mg for 4 days and the other group received CO-AMOXICLAV 625mg, 3 times a day for 10 days. Patients were visited 4 times during the study (baseline, phone call, end of treatment, end of study) and regression/progression of their symptoms and their response to the treatment was evaluated.Results: There was no significant difference between the two groups' demographic and clinical presentations. Duration of regression of the symptoms in the AZITHROMYCIN group was significantly shorter than the CO-AMOXICLAV group (7.6 days versus 10.6, p=0.03). Clinical success rate at end of the study was 80% for AZITHROMYCIN and 66.7% for CO-AMOXICLAV (p=0.025). Clinical success rates among females in both groups seemed to be higher than males, but this difference was not statistically significant (p=0.13).Conclusion: Results revealed that AZITHROMYCIN regimen is more efficient, has less side effects, and required shorter treatment period. Patients were able to tolerate the medications better with a higher compliance and less economic cost than CO-AMOXICLAV regimen.

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APA: Copy

RASTEGAR LARI, ABDOLAZIZ, GHAFFARIYEH, ALIREZA, ETESAM, NOUSHIN, MOSTAFAVI, HAMID, & ALAGHEHBANDAN, REZA. (2010). A RANDOMIZED CONTROLLED TRIAL OF 5-DAY REGIMEN OF AZITHROMYCIN AND A 10-DAY REGIMEN OF CO-AMOXICLAV FOR TREATMENT OF ACUTE SINUSITIS. IRANIAN JOURNAL OF CLINICAL INFECTIOUS DISEASES, 5(3), 137-141. SID. https://sid.ir/paper/313680/en

Vancouver: Copy

RASTEGAR LARI ABDOLAZIZ, GHAFFARIYEH ALIREZA, ETESAM NOUSHIN, MOSTAFAVI HAMID, ALAGHEHBANDAN REZA. A RANDOMIZED CONTROLLED TRIAL OF 5-DAY REGIMEN OF AZITHROMYCIN AND A 10-DAY REGIMEN OF CO-AMOXICLAV FOR TREATMENT OF ACUTE SINUSITIS. IRANIAN JOURNAL OF CLINICAL INFECTIOUS DISEASES[Internet]. 2010;5(3):137-141. Available from: https://sid.ir/paper/313680/en

IEEE: Copy

ABDOLAZIZ RASTEGAR LARI, ALIREZA GHAFFARIYEH, NOUSHIN ETESAM, HAMID MOSTAFAVI, and REZA ALAGHEHBANDAN, “A RANDOMIZED CONTROLLED TRIAL OF 5-DAY REGIMEN OF AZITHROMYCIN AND A 10-DAY REGIMEN OF CO-AMOXICLAV FOR TREATMENT OF ACUTE SINUSITIS,” IRANIAN JOURNAL OF CLINICAL INFECTIOUS DISEASES, vol. 5, no. 3, pp. 137–141, 2010, [Online]. Available: https://sid.ir/paper/313680/en

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