LACK OF ASSOCIATION BETWEEN TUMOR NECROSIS FACTOR-ALPHA -308 G/A POLYMORPHISM AND RISK OF DEVELOPING LATE-ONSET ALZHEIMER'S DISEASE IN AN IRANIAN POPULATION

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MANOUCHEHRI MAHDI; KAMALI KOUROSH; RAHGOZAR MAHDI; OUHADI M.; FAROKHI H.; KHORAM KHOURSHID H.R.

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Journal Paper

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Journal: Avicenna Journal of Medical Biotechnology Year:2009 | Volume:1 | Issue:3 Page(s): 193-197

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Title

LACK OF ASSOCIATION BETWEEN TUMOR NECROSIS FACTOR-ALPHA -308 G/A POLYMORPHISM AND RISK OF DEVELOPING LATE-ONSET ALZHEIMER'S DISEASE IN AN IRANIAN POPULATION

Author(s)

Keywords

ALZHEIMER’S DISEASE

GENETIC ASSOCIATION STUDY

POLYMORPHISM

POPULATION

TNF-α

GENE

Abstract

Introduction: Late-onset Alzheimer's Disease (LOAD) is a neurodegenerative disorder and the most common form of dementia affecting people over 65 years old. ALZHEIMER’S DISEASE is a complex disease with multi-factorial etiology. Inflammation has been approved to have an important role in the pathogenesis of ALZHEIMER’S DISEASE (AD). TNF-a is a main pro-inflammatory cytokine that plays an essential role in initiation and regulation of inflammatory responses. Several studies have shown the probable association of POLYMORPHISM at TNF-a gene’s promoter with AD pathogenesis. This study was performed to determine whether this POLYMORPHISM contributes to the risk for late-onset Alzheimer's disease (LOAD) in Iranian POPULATION. One hundred and forty AD patients and 158 healthy controls were recruited in the study. Following extraction of genomic DNA, using PCR/RFLP methods the genotype and allele frequencies were determined in case and control subjects. The statistical analysis showed no significant difference in the allele and genotype frequencies due to this POLYMORPHISM between the two groups. Also after stratifying the subjects by their APOE-e 4 status, no significant association was observed. Our results suggest that Tumor necrosis factor-alpha (TNF-a) -308 G/A is not a risk or protective factor for late-onset ALZHEIMER’S DISEASE in Iranian POPULATION. However, to confirm these results further study with a bigger sample size may be required.

Cites

AN ASSOCIATION STUDY ON IL16 GENE POLYMORPHISMS WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE

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APA: Copy

MANOUCHEHRI, MAHDI, KAMALI, KOUROSH, RAHGOZAR, MAHDI, OUHADI, M., FAROKHI, H., & KHORAM KHOURSHID, H.R.. (2009). LACK OF ASSOCIATION BETWEEN TUMOR NECROSIS FACTOR-ALPHA -308 G/A POLYMORPHISM AND RISK OF DEVELOPING LATE-ONSET ALZHEIMER'S DISEASE IN AN IRANIAN POPULATION. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 1(3), 193-197. SID. https://sid.ir/paper/313709/en

Vancouver: Copy

MANOUCHEHRI MAHDI, KAMALI KOUROSH, RAHGOZAR MAHDI, OUHADI M., FAROKHI H., KHORAM KHOURSHID H.R.. LACK OF ASSOCIATION BETWEEN TUMOR NECROSIS FACTOR-ALPHA -308 G/A POLYMORPHISM AND RISK OF DEVELOPING LATE-ONSET ALZHEIMER'S DISEASE IN AN IRANIAN POPULATION. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2009;1(3):193-197. Available from: https://sid.ir/paper/313709/en

IEEE: Copy

MAHDI MANOUCHEHRI, KOUROSH KAMALI, MAHDI RAHGOZAR, M. OUHADI, H. FAROKHI, and H.R. KHORAM KHOURSHID, “LACK OF ASSOCIATION BETWEEN TUMOR NECROSIS FACTOR-ALPHA -308 G/A POLYMORPHISM AND RISK OF DEVELOPING LATE-ONSET ALZHEIMER'S DISEASE IN AN IRANIAN POPULATION,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 1, no. 3, pp. 193–197, 2009, [Online]. Available: https://sid.ir/paper/313709/en

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