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Information Journal Paper

Title

AN ASSOCIATION STUDY ON IL16 GENE POLYMORPHISMS WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE

Pages

  128-132

Abstract

 Background: INTERLEUKIN-16 (IL-16) is an important regulator of T cell activation and was reported to act as a chemoattractant agent. There are evidences that IL16 can control the neuroinflammatory processes in ALZHEIMER’S DISEASE (AD). This study was performed to investigate the role or association of IL16 POLYMORPHISMs, rs11556218 and rs4778889 with the risk of late-onset ALZHEIMER’S DISEASE (LOAD) in Iranian population.Methods: Totally, 148 AD patients and 137 nondemented and age-matched subjects were recruited in this study. Genotyping of rs11556218 T/G and rs4778889 T/C POLYMORPHISMs was performed by PCR-RFLP method using the NdeI and AhdI restriction enzymes, respectively.Results: Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16) as well as rs4778889 (p=0.001, OR=0.23). Frequency of rs11556218 allele T was higher in controls than patients (p=0.001, OR=0.32). However, there was no significant difference in the frequencies of rs4778889 alleles between the AD patients and controls.Conclusion: Our results indicate that the rs11556218 and rs4778889 POLYMORPHISMs have a protective role in the development of sporadic AD in Iranian population.

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    APA: Copy

    KHOSHBAKHT, TAYYEBEH, SOOSANABADI, MOHSEN, NEISHABOURY, MARYAM, KAMALI, KOOROSH, KARIMLOU, MASOUD, BAZAZZADEGAN, NILOFAR, & KHORRAM KHORSHID, HAMID REZA. (2015). AN ASSOCIATION STUDY ON IL16 GENE POLYMORPHISMS WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 7(3), 128-132. SID. https://sid.ir/paper/313873/en

    Vancouver: Copy

    KHOSHBAKHT TAYYEBEH, SOOSANABADI MOHSEN, NEISHABOURY MARYAM, KAMALI KOOROSH, KARIMLOU MASOUD, BAZAZZADEGAN NILOFAR, KHORRAM KHORSHID HAMID REZA. AN ASSOCIATION STUDY ON IL16 GENE POLYMORPHISMS WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2015;7(3):128-132. Available from: https://sid.ir/paper/313873/en

    IEEE: Copy

    TAYYEBEH KHOSHBAKHT, MOHSEN SOOSANABADI, MARYAM NEISHABOURY, KOOROSH KAMALI, MASOUD KARIMLOU, NILOFAR BAZAZZADEGAN, and HAMID REZA KHORRAM KHORSHID, “AN ASSOCIATION STUDY ON IL16 GENE POLYMORPHISMS WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 7, no. 3, pp. 128–132, 2015, [Online]. Available: https://sid.ir/paper/313873/en

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