CHARACTERIZATION AND FUNCTIONAL ASSESSMENT OF MOUSE PPARγ1 PROMOTER

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LACHINANI LIANA; GHAEDI KAMRAN; TANHAEI SOMAYEH; SALAMIAN AHMAD; KARAMALI FERESHTEH; KIANI ESFAHANI ABBAS; RABIEE FARZANEH; YAGHMAEI PARICHEHREH; BAHARVAND HOSSEIN; NASRESFAHANI MOHAMMAD HOSSEIN

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Journal: Avicenna Journal of Medical Biotechnology Year:2012 | Volume:4 | Issue:4 (15) Page(s): 160-169

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Title

CHARACTERIZATION AND FUNCTIONAL ASSESSMENT OF MOUSE PPARγ1 PROMOTER

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Keywords

PPAR GAMMA

MOUSE

GENE EXPRESSION

Abstract

Background: Peroxisome Proliferator Activated Receptor gamma (PPARg), a member of nuclear receptor superfamily, comprises two isoforms in MOUSE.These two isoforms are encoded by different mRNAs, which are arisen by alternative promoter usage. There are two promoter regions upstream of PPARg gene. A 3 kb fragment, containing several transcription factor binding sites, acts as PPARg1 promoter region. Thus, expression pattern of PPARg1 isoform is due to the potential transcription factors that could influence its promoter activity. PPARg, Retinoid X Receptor (RXR) and Vitamin D Receptor (VDR), as nuclear receptors could influence PPARg GENE EXPRESSION pattern during several differentiation processes. During neural differentiation, PPARg1 isoform expression reaches to maximal level at neural precursor cell formation.Methods: A vast computational analysis was carried out to reveal the PPARg1 promoter region. The putative promoter region was then subcloned upstream of an EGFP reporter gene. Then the functionality of PPARg1 promoter was assessed in different cell lines.Results: Results indicated that Rosiglitazone increased PPARg1 promoter regulated EGFP expression of neural precursor cells during Embryoid Body (EB) formation. Furthermore vitamin D reduced PPARg1 promoter regulated EGFP expression of neural precursor cells during EB formation through binding to its receptor.Conclusion: This study suggests that there are potential response elements for PPAR/RXR and VDR/RXR heterodimers in PPARg1 isoform promoter. Also VDR/RXR heterodimers may decrease PPARg expression through binding to its promoter.

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APA: Copy

LACHINANI, LIANA, GHAEDI, KAMRAN, TANHAEI, SOMAYEH, SALAMIAN, AHMAD, KARAMALI, FERESHTEH, KIANI ESFAHANI, ABBAS, RABIEE, FARZANEH, YAGHMAEI, PARICHEHREH, BAHARVAND, HOSSEIN, & NASRESFAHANI, MOHAMMAD HOSSEIN. (2012). CHARACTERIZATION AND FUNCTIONAL ASSESSMENT OF MOUSE PPARγ1 PROMOTER. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 4(4 (15)), 160-169. SID. https://sid.ir/paper/313791/en

Vancouver: Copy

LACHINANI LIANA, GHAEDI KAMRAN, TANHAEI SOMAYEH, SALAMIAN AHMAD, KARAMALI FERESHTEH, KIANI ESFAHANI ABBAS, RABIEE FARZANEH, YAGHMAEI PARICHEHREH, BAHARVAND HOSSEIN, NASRESFAHANI MOHAMMAD HOSSEIN. CHARACTERIZATION AND FUNCTIONAL ASSESSMENT OF MOUSE PPARγ1 PROMOTER. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2012;4(4 (15)):160-169. Available from: https://sid.ir/paper/313791/en

IEEE: Copy

LIANA LACHINANI, KAMRAN GHAEDI, SOMAYEH TANHAEI, AHMAD SALAMIAN, FERESHTEH KARAMALI, ABBAS KIANI ESFAHANI, FARZANEH RABIEE, PARICHEHREH YAGHMAEI, HOSSEIN BAHARVAND, and MOHAMMAD HOSSEIN NASRESFAHANI, “CHARACTERIZATION AND FUNCTIONAL ASSESSMENT OF MOUSE PPARγ1 PROMOTER,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 4, no. 4 (15), pp. 160–169, 2012, [Online]. Available: https://sid.ir/paper/313791/en

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