مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

INTRAVENOUS TRANSPLANTATION OF VERY SMALL EMBRYONIC LIKE STEM CELLS IN TREATMENT OF DIABETES MELLITUS

Pages

  22-31

Abstract

 Background: DIABETES MELLITUS (DM), simply known as diabetes, refers to a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. In this study, the feasibility and safety of intravenous TRANSPLANTATION of VERY SMALL EMBRYONIC LIKE STEM CELLS (VSELs) were investigated for diabetes repair, and finally the migration and distribution of these cells in hosts were observed.Methods: Mouse bone marrow VSELs were isolated by Fluorescent Activating Cell Sorting (FACS) method by using fluorescent antibodies against CD45, CXCR4 and Sca1 markers. Sorted cells were analyzed for expression of oct4 and SSEA1 markers with immunocytochemistry staining method. To determine multilineage differentiation, sorted cells were differentiated to Schwann, osteocyte and beta cells. Ten days after the establishment of a mouse model of pancreas necrosis, DiI-labeled VSELs were in-jected into these mice via tail vein. Pancreases were harvested 4 weeks after trans-plantation and the sections of these tissues were observed under fluorescent micro-scope.Results: It was proved that CD45-, CXCR4+, and Sca1+sorted cells express oct4 and SSEA1. Our results revealed that intravenously implanted VSELs could migrate into the pancreas of hosts and survive in the diabetic pancreas. In treated groups, blood glucose decreased significantly for at least two month and the weights of mice in-creased gradually.Conclusion: This study provides a strategy for using VSELs for curing diabetes and other regenerative diseases, and the strategy is considered an alternative for other stem cell types.

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    Cite

    APA: Copy

    ABOUZARIPOUR, MORTEZA, RAGERDI KASHANI, IRAJ, PASBAKHSH, PARICHEHR, & ATLASY, NADER. (2015). INTRAVENOUS TRANSPLANTATION OF VERY SMALL EMBRYONIC LIKE STEM CELLS IN TREATMENT OF DIABETES MELLITUS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 7(1), 22-31. SID. https://sid.ir/paper/313862/en

    Vancouver: Copy

    ABOUZARIPOUR MORTEZA, RAGERDI KASHANI IRAJ, PASBAKHSH PARICHEHR, ATLASY NADER. INTRAVENOUS TRANSPLANTATION OF VERY SMALL EMBRYONIC LIKE STEM CELLS IN TREATMENT OF DIABETES MELLITUS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2015;7(1):22-31. Available from: https://sid.ir/paper/313862/en

    IEEE: Copy

    MORTEZA ABOUZARIPOUR, IRAJ RAGERDI KASHANI, PARICHEHR PASBAKHSH, and NADER ATLASY, “INTRAVENOUS TRANSPLANTATION OF VERY SMALL EMBRYONIC LIKE STEM CELLS IN TREATMENT OF DIABETES MELLITUS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 7, no. 1, pp. 22–31, 2015, [Online]. Available: https://sid.ir/paper/313862/en

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