HIGH PREVALENCE OF Y CHROMOSOME PARTIAL MICRODELETIONS IN OVERWEIGHT MEN

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BIABANGARD ZAK ATEFEH; GOLALIPOUR MASOUD; HADADCHI GHOLAMREZA

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Paper Information

Journal: Avicenna Journal of Medical Biotechnology Year:2015 | Volume:7 | Issue:3 Page(s): 97-100

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Title

HIGH PREVALENCE OF Y CHROMOSOME PARTIAL MICRODELETIONS IN OVERWEIGHT MEN

Author(s)

BIABANGARD ZAK ATEFEH | GOLALIPOUR MASOUD | HADADCHI GHOLAMREZA | Issue Writer Certificate

Keywords

OBESITY

TESTOSTERONE

Y CHROMOSOME MICRODELETIONS

Abstract

Background: Microdeletions of the Y chromosome are one of the most frequent genetic causes of spermatogenic failure in infertile men. But their role in gaining weight is unclear. The present study investigated the possible association of these partial microdeletions and OBESITY.Methods: In a case-control study, 180 males were selected. The prevalence of microdeletions was assessed using PCR in AZFc area of Y chromosome and statistical analysis was done using the Fisher exact test and Pearson correlation.Results: In our study, inverse relationship was observed between body mass index and TESTOSTERONE level (p-value: 0.005). Fisher exact tests showed that there was a significant association between gr/gr mutation and BMI (p-value: 0.044).Conclusion: Our study revealed that Y CHROMOSOME MICRODELETIONS are more common in obese men. Furthermore, microdeletions such as gr/gr, which were observed in normal men, could cause decreased TESTOSTERONE level. So, they may contribute to gaining weight.

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APA: Copy

BIABANGARD ZAK, ATEFEH, GOLALIPOUR, MASOUD, & HADADCHI, GHOLAMREZA. (2015). HIGH PREVALENCE OF Y CHROMOSOME PARTIAL MICRODELETIONS IN OVERWEIGHT MEN. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 7(3), 97-100. SID. https://sid.ir/paper/313872/en

Vancouver: Copy

BIABANGARD ZAK ATEFEH, GOLALIPOUR MASOUD, HADADCHI GHOLAMREZA. HIGH PREVALENCE OF Y CHROMOSOME PARTIAL MICRODELETIONS IN OVERWEIGHT MEN. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2015;7(3):97-100. Available from: https://sid.ir/paper/313872/en

IEEE: Copy

ATEFEH BIABANGARD ZAK, MASOUD GOLALIPOUR, and GHOLAMREZA HADADCHI, “HIGH PREVALENCE OF Y CHROMOSOME PARTIAL MICRODELETIONS IN OVERWEIGHT MEN,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 7, no. 3, pp. 97–100, 2015, [Online]. Available: https://sid.ir/paper/313872/en

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