مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION OF TRANSFORMING GROWTH FACTOR ALPHA POLYMORPHISMS WITH NONSYNDROMIC CLEFT LIP AND PALATE IN IRANIAN POPULATION

Pages

  168-172

Abstract

 Background: Cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies and the etiology of orofacial clefts is multifactorial. TRANSFORMING GROWTH FACTOR ALPHA (TGFA) is expressed at the medial edge epithelium of fusing palatal shelves during craniofacial development. In this study, the association of two important TGFA gene POLYMORPHISMs, BamHI (rs11466297) and RsaI (rs3732248), with CL/P was evaluated in an Iranian population.Methods: The frequencies of BamHI and RsaI variations were determined in 105 unre-lated Iranian subjects with nonsyndromic CL/P and 218 control subjects using PCR and RFLP methods, and the results were compared with healthy controls. A p- value of <0.05 was considered statistically significant.Results: The BamHI AC genotype was significantly higher (Pp=0.016) in the patients (12.4%) than the control group (5.0%). The BamHI C allele was significantly higher (pP=0.001; OR=3.4, 95% CI: 1.6- 7.4) in the cases (8.0%) compared with the control group (2.5%).Conclusion: Our study showed that there was an association between the TGFA BamHI variation and nonsyndromic CL/P in Iranian population.

Cites

References

Cite

APA: Copy

EBADIFAR, ASGHAR, HAMEDI, ROYA, KHORRAM KHORSHID, HAMID REZA, SALIMINEJAD, KIOOMARS, KAMALI, KOOROSH, AGHAKHANI MOGHADAM, FATEMEH, ESMAEILI ANVAR, NAZANIN, & AMELI, NAZILLA. (2015). ASSOCIATION OF TRANSFORMING GROWTH FACTOR ALPHA POLYMORPHISMS WITH NONSYNDROMIC CLEFT LIP AND PALATE IN IRANIAN POPULATION. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 7(4 (27)), 168-172. SID. https://sid.ir/paper/313887/en

Vancouver: Copy

EBADIFAR ASGHAR, HAMEDI ROYA, KHORRAM KHORSHID HAMID REZA, SALIMINEJAD KIOOMARS, KAMALI KOOROSH, AGHAKHANI MOGHADAM FATEMEH, ESMAEILI ANVAR NAZANIN, AMELI NAZILLA. ASSOCIATION OF TRANSFORMING GROWTH FACTOR ALPHA POLYMORPHISMS WITH NONSYNDROMIC CLEFT LIP AND PALATE IN IRANIAN POPULATION. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2015;7(4 (27)):168-172. Available from: https://sid.ir/paper/313887/en

IEEE: Copy

ASGHAR EBADIFAR, ROYA HAMEDI, HAMID REZA KHORRAM KHORSHID, KIOOMARS SALIMINEJAD, KOOROSH KAMALI, FATEMEH AGHAKHANI MOGHADAM, NAZANIN ESMAEILI ANVAR, and NAZILLA AMELI, “ASSOCIATION OF TRANSFORMING GROWTH FACTOR ALPHA POLYMORPHISMS WITH NONSYNDROMIC CLEFT LIP AND PALATE IN IRANIAN POPULATION,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 7, no. 4 (27), pp. 168–172, 2015, [Online]. Available: https://sid.ir/paper/313887/en

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