TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6 GENE POLYMORPHISMS IN IRANIAN PATIENTS WITH ISCHEMIC HEART FAILURE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEDAYAT MONA; MAHMOUDI MOHAMMAD JAFAR; TAGHVAEI MOHAMMAD; NEMATIPOOR EBRAHIM; FARHADI ELHAM; ESFAHANIAN NILOUFAR; MAHMOUDI MARYAM; SADR MARYAM; NOURIJELYANI KERAMAT; AMIRZARGAR ALI AKBAR; REZAEI NIMA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biotechnology Year:2018 | Volume:10 | Issue:2 Page(s): 105-109

Download Full-Text

View:

343

Download:

274

Cites:

Information Journal Paper

Title

TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6 GENE POLYMORPHISMS IN IRANIAN PATIENTS WITH ISCHEMIC HEART FAILURE

Author(s)

Keywords

GENES

HEART FAILURE

INTERLEUKIN-6

TUMOR NECROSIS FACTOR-ALPHA

Abstract

Background: Proinflammatory cytokines have been known to be elevated in patients with Chronic HEART FAILURE (CHF). Given the importance of proinflammatory cytokines in the context of the failing heart, the prevalence of Tumor Necrosis Factor-a (TNF-a), Interleukin (IL) -6 polymorphisms in patients with CHF was studied due to ischemic heart disease.Methods: Forty three patients with ischemic HEART FAILURE were enrolled in this study and compared with 140 healthy individuals. The allele and genotype frequency of four Single Nucleotide Polymorphisms (SNPs) within the IL-6 (-174, nt565) and TNF-a (-308, -238) GENES were determined, using Polymerase Chain Reaction with Sequence-Specific Primers (PCR-SSP) assay.Results: The frequency of the TNF-a (-238) A/A genotype was significantly higher in patients comparing to controls (p=0.043), while TNF-a G/A genotype at the same position decreased significantly, in comparison with controls (p=0.018). The most frequent haplotype for TNF-a was A/A in the patient group in comparison with controls (p=0.003). There was no significant difference in allele and genotype frequencies of IL-6 at positions -174 and nt565, and TNF-a at position -308.Conclusion: Certain alleles, genotypes, and haplotypes in TNF-a, but not IL-6, gene were overrepresented in patients with ischemic HEART FAILURE, which may, in turn, predispose individuals to this disease.

Cites

No record.

References

No record.

Cite

APA: Copy

HEDAYAT, MONA, MAHMOUDI, MOHAMMAD JAFAR, TAGHVAEI, MOHAMMAD, NEMATIPOOR, EBRAHIM, FARHADI, ELHAM, ESFAHANIAN, NILOUFAR, MAHMOUDI, MARYAM, SADR, MARYAM, NOURIJELYANI, KERAMAT, AMIRZARGAR, ALI AKBAR, & REZAEI, NIMA. (2018). TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6 GENE POLYMORPHISMS IN IRANIAN PATIENTS WITH ISCHEMIC HEART FAILURE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 10(2), 105-109. SID. https://sid.ir/paper/313961/en

Vancouver: Copy

HEDAYAT MONA, MAHMOUDI MOHAMMAD JAFAR, TAGHVAEI MOHAMMAD, NEMATIPOOR EBRAHIM, FARHADI ELHAM, ESFAHANIAN NILOUFAR, MAHMOUDI MARYAM, SADR MARYAM, NOURIJELYANI KERAMAT, AMIRZARGAR ALI AKBAR, REZAEI NIMA. TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6 GENE POLYMORPHISMS IN IRANIAN PATIENTS WITH ISCHEMIC HEART FAILURE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2018;10(2):105-109. Available from: https://sid.ir/paper/313961/en

IEEE: Copy

MONA HEDAYAT, MOHAMMAD JAFAR MAHMOUDI, MOHAMMAD TAGHVAEI, EBRAHIM NEMATIPOOR, ELHAM FARHADI, NILOUFAR ESFAHANIAN, MARYAM MAHMOUDI, MARYAM SADR, KERAMAT NOURIJELYANI, ALI AKBAR AMIRZARGAR, and NIMA REZAEI, “TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6 GENE POLYMORPHISMS IN IRANIAN PATIENTS WITH ISCHEMIC HEART FAILURE,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 10, no. 2, pp. 105–109, 2018, [Online]. Available: https://sid.ir/paper/313961/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops