EVALUATING THE FREQUENCY OF AAC (6')-IIA, ANT (2'')-I, INTL1, AND INTL2 GENES IN AMINOGLYCOSIDES RESISTANT KLEBSIELLA PNEUMONIAE ISOLATES OBTAINED FROM HOSPITALIZED PATIENTS IN YAZD, IRAN

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MOKHTARI HESAM; ESLAMI GILDA; ZANDI HENGAMEH; Dehghan Banadkouki Amin; VAKILI MAHMOOD

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Journal: Avicenna Journal of Medical Biotechnology Year:2018 | Volume:10 | Issue:2 Page(s): 115-119

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Title

EVALUATING THE FREQUENCY OF AAC (6')-IIA, ANT (2'')-I, INTL1, AND INTL2 GENES IN AMINOGLYCOSIDES RESISTANT KLEBSIELLA PNEUMONIAE ISOLATES OBTAINED FROM HOSPITALIZED PATIENTS IN YAZD, IRAN

Author(s)

Keywords

AMINOGLYCOSIDES

DRUG RESISTANCE

INTEGRONS

KLEBSIELLA PNEUMONIAE

MICROBIAL

Abstract

Background: KLEBSIELLA PNEUMONIAE (K. pneumoniae) is an opportunistic pathogen that could be resistant to many antimicrobial agents. Resistance genes can be carried among gram-negative bacteria by INTEGRONS. Enzymatic inactivation is the most important mechanism of resistance to AMINOGLYCOSIDES. In this study, the frequencies of two important resistance geneaac (6’) -IIa and ant (2’’) -I, and genes coding integrase I and II, inK. pneumoniae isolates resistant to AMINOGLYCOSIDES were evaluated.Methods: In this cross-sectional study, an attempt was made to assess the antibiotic susceptibility of 130K. pneumoniae isolates obtained from different samples of patients hospitalized in training hospitals of Yazd evaluated by disk diffusion method.The frequencies ofaac (6’) -IIa, ant (2’’) -I, intl1, and intl2 genes were determined by PCR method. Data were analyzed by chi-square method using SPSS software (Ver.16).Results: our results showed that resistance to gentamicin, tobramycin, kanamycin, and amikacin were 34.6, 33.8, 43.8, and 14.6%, respectively. The frequencies ofaac (6’) -IIa, ant (2’’) -I, intl1, and intl2 genes were 44.6, 27.7, 90, and 0%, respectively.Conclusion: This study showed there are high frequencies of genes coding AMINOGLYCOSIDES resistance inK. pneumoniae isolates. Hence, it is very important to monitor and inhibit the spread of antibiotic resistance genes.

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APA: Copy

MOKHTARI, HESAM, ESLAMI, GILDA, ZANDI, HENGAMEH, Dehghan Banadkouki, Amin, & VAKILI, MAHMOOD. (2018). EVALUATING THE FREQUENCY OF AAC (6')-IIA, ANT (2'')-I, INTL1, AND INTL2 GENES IN AMINOGLYCOSIDES RESISTANT KLEBSIELLA PNEUMONIAE ISOLATES OBTAINED FROM HOSPITALIZED PATIENTS IN YAZD, IRAN. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 10(2), 115-119. SID. https://sid.ir/paper/313966/en

Vancouver: Copy

MOKHTARI HESAM, ESLAMI GILDA, ZANDI HENGAMEH, Dehghan Banadkouki Amin, VAKILI MAHMOOD. EVALUATING THE FREQUENCY OF AAC (6')-IIA, ANT (2'')-I, INTL1, AND INTL2 GENES IN AMINOGLYCOSIDES RESISTANT KLEBSIELLA PNEUMONIAE ISOLATES OBTAINED FROM HOSPITALIZED PATIENTS IN YAZD, IRAN. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2018;10(2):115-119. Available from: https://sid.ir/paper/313966/en

IEEE: Copy

HESAM MOKHTARI, GILDA ESLAMI, HENGAMEH ZANDI, Amin Dehghan Banadkouki, and MAHMOOD VAKILI, “EVALUATING THE FREQUENCY OF AAC (6')-IIA, ANT (2'')-I, INTL1, AND INTL2 GENES IN AMINOGLYCOSIDES RESISTANT KLEBSIELLA PNEUMONIAE ISOLATES OBTAINED FROM HOSPITALIZED PATIENTS IN YAZD, IRAN,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 10, no. 2, pp. 115–119, 2018, [Online]. Available: https://sid.ir/paper/313966/en

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