Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

265
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

207
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

MAGNETIC IRON OXIDE NANOPARTICLES AS T2 MR IMAGING CONTRAST AGENT FOR DETECTION OF BREAST CANCER (MCF-7) CELL

Pages

  181-188

Abstract

 Background: Advances of nanotechnology have led to the development of nanomaterials with both potential diagnostic and therapeutic applications. Among them, Super Paramagnetic Iron Oxide NANOPARTICLES (SPIONs) have received particular attention. Modified EDC coupling fraction was used to fabricate the SPION-C595 as an MR imaging contrast agent for BREAST CANCER detection in early stages.Methods: Nanoprobe characterization was confirmed using Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy with Energy Dispersive X-Ray Spectroscopy (SEM-EDAX), and Photon Correlation Spectroscopy (PCS). Protein and iron concentration of nanoprobe was examined by standard method. MTT assay was performed to evaluate the cytotoxicity of the nanoprobe in BREAST CANCER cell line (MCF-7). T2-weighted MR imaging was performed to evaluate the signal enhancement on T2 relaxation time of nanoprobe using spin-echo pulse sequence.Results: As results showed, SPIONs-C595 provided active targeting of BREAST CANCER cell (MCF-7) at a final concentration of 600 mgFe/ml. The final concentration of protein was calculated to be at 0.78 mgprotein/ml. The hydrodynamic size of the nanoprobe was 87.4±0.7 nm. The MR imaging results showed a good reduction of T2 relaxation rates for the highest dose of SPIONs-C595.Discussion: Based on the results, SPIONs-C595 nanoprobe has a potential in T2- weighted MR imaging contrast agent for BREAST CANCER cell (MCF-7) detection.

Cites

References

  • No record.

    • Cite

    APA: Copy

    Moradi Khaniabadi, Pegah, SHAHBAZI GAHROUEI, DARYOUSH, SUHAIMI JAAFAR, MOHAMMAD, ABDUL MAJID, AMIN MALIK SHAH, MORADI KHANIABADI, BITA, & SHAHBAZI GAHROUEI, SAGHAR. (2017). MAGNETIC IRON OXIDE NANOPARTICLES AS T2 MR IMAGING CONTRAST AGENT FOR DETECTION OF BREAST CANCER (MCF-7) CELL. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(4), 181-188. SID. https://sid.ir/paper/313971/en

    Vancouver: Copy

    Moradi Khaniabadi Pegah, SHAHBAZI GAHROUEI DARYOUSH, SUHAIMI JAAFAR MOHAMMAD, ABDUL MAJID AMIN MALIK SHAH, MORADI KHANIABADI BITA, SHAHBAZI GAHROUEI SAGHAR. MAGNETIC IRON OXIDE NANOPARTICLES AS T2 MR IMAGING CONTRAST AGENT FOR DETECTION OF BREAST CANCER (MCF-7) CELL. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(4):181-188. Available from: https://sid.ir/paper/313971/en

    IEEE: Copy

    Pegah Moradi Khaniabadi, DARYOUSH SHAHBAZI GAHROUEI, MOHAMMAD SUHAIMI JAAFAR, AMIN MALIK SHAH ABDUL MAJID, BITA MORADI KHANIABADI, and SAGHAR SHAHBAZI GAHROUEI, “MAGNETIC IRON OXIDE NANOPARTICLES AS T2 MR IMAGING CONTRAST AGENT FOR DETECTION OF BREAST CANCER (MCF-7) CELL,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 4, pp. 181–188, 2017, [Online]. Available: https://sid.ir/paper/313971/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top