THE EFFECT OF INTERACTIONS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF APOA1/APOC3 WITH FOOD GROUP INTAKES ON THE RISK OF METABOLIC SYNDROME

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HOSSEINI ESFAHANI FIROOZEH; MIRMIRAN PARVIN; DANESHPOUR MARYAM S.; MOTTAGHI AZADEH; AZIZI FEREIDOUN

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Journal: Avicenna Journal of Medical Biotechnology Year:2017 | Volume:9 | Issue:2 Page(s): 94-103

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Title

THE EFFECT OF INTERACTIONS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF APOA1/APOC3 WITH FOOD GROUP INTAKES ON THE RISK OF METABOLIC SYNDROME

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Keywords

FOOD

GENETIC POLYMORPHISMS

METABOLIC SYNDROME

Abstract

Background: The aim of this study was to examine the interaction of dietary FOOD groups and genetic variants of APOA1/APOC3, relative to METABOLIC SYNDROME (MetS) risk in adults.Methods: In this matched nested case-control study, 414 MetS subjects and 414 controls were selected from among participants of Tehran Lipid and Glucose Study. Dietary intake was assessed with the use of a valid and reliable semi-quantitative FOOD frequency questionnaire. Single Nucleotide Polymorphisms (SNPs), APOA1 (rs670, -75G>A and rs5069, +83C>T/APOC3 rs5128 C3238>G) were genotyped by the conventional polymerase chain reaction and restriction fragment length polymorphism.Results: The mean (SD) of age was 40.7 (13) and 41.2 (13) years in male cases and controls versus 44.0 (11) and 44.0 (12) years in female case and controls. A significant interaction between intake quartiles of the sugar group and APOA1 combined group (GA+AA/CT+TT) SNPs was found; The ORs for these genotype carriers were (1, 0.44, 0.36, 0.23; P trend<0.001) in quartiles of intake, relative to other combined genotypes (P interaction=0.02). MetS risk appeared to be increased significantly in higher quartiles of sweet beverages and fish intakes in the GA+AA/CT+TT/CC genotypes of APOA1/APOC3 SNPs, compared to other genotypes (P interaction=0.01). The combined effect of genotypes of APOC3/APOA1 showed further decrease in MetS risk in higher quartiles of sugar group intakes (OR: 1, 0.24, 0.26, 0.14, P trend=0.001) relative to other combinations (P interaction=0.008).Conclusion: Results obtained demonstrate that some dietary FOOD groups (sugar, fish, and sweet beverages) modulate the effect of APOA1/APOC3 SNPs in relation to MetS risk.

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APA: Copy

HOSSEINI ESFAHANI, FIROOZEH, MIRMIRAN, PARVIN, DANESHPOUR, MARYAM S., MOTTAGHI, AZADEH, & AZIZI, FEREIDOUN. (2017). THE EFFECT OF INTERACTIONS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF APOA1/APOC3 WITH FOOD GROUP INTAKES ON THE RISK OF METABOLIC SYNDROME. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(2), 94-103. SID. https://sid.ir/paper/313981/en

Vancouver: Copy

HOSSEINI ESFAHANI FIROOZEH, MIRMIRAN PARVIN, DANESHPOUR MARYAM S., MOTTAGHI AZADEH, AZIZI FEREIDOUN. THE EFFECT OF INTERACTIONS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF APOA1/APOC3 WITH FOOD GROUP INTAKES ON THE RISK OF METABOLIC SYNDROME. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(2):94-103. Available from: https://sid.ir/paper/313981/en

IEEE: Copy

FIROOZEH HOSSEINI ESFAHANI, PARVIN MIRMIRAN, MARYAM S. DANESHPOUR, AZADEH MOTTAGHI, and FEREIDOUN AZIZI, “THE EFFECT OF INTERACTIONS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF APOA1/APOC3 WITH FOOD GROUP INTAKES ON THE RISK OF METABOLIC SYNDROME,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 2, pp. 94–103, 2017, [Online]. Available: https://sid.ir/paper/313981/en

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