Single Nucleotide Polymorphism of TYK2 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population

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Mohamadhosseini Azadeh; MANSOURI REZA; JAVINANI ALI; Ganjouei Amir Ashraf; Akhlaghi Massoumeh; ASLANI SAEED; Hamzeh Elham; Jamshidi Ahmadreza; AHMADZADEH NOOSHIN; MAHMOUDI MAHDI

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Journal: Avicenna Journal of Medical Biotechnology Year:2019 | Volume:11 | Issue:2 Page(s): 187-191

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Title

Single Nucleotide Polymorphism of TYK2 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population

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Keywords

Rheumatoid arthritis

Single nucleotide polymorphism

TYK2 kinase

Abstract

Background: Rheumatoid arthritis (RA) is a debilitating disorder in which the im-mune system mainly targets the synovial tissue. Janus kinase family including tyrosine kinase 2 (TYK2) is one of the crucial mediators of the downstream signaling pathway of inflammatory cytokines that further contributes to RA pathogenesis. In this study, the association of TYK2 gene rs34536443 polymorphism, which may affect the func-tion of TYK protein and, hence, the inflammatory settings, with RA susceptibility was investigated. Moreover, its correlation with demographic and serological features of the patients was assessed. Methods: In the present study, 700 RA patients and 700 sex, age and ethnicity-matched healthy individuals as the control group were included. MGB TaqMan real-time allelic discrimination method was used to determine the rs34536443 polymor-phism. Rheumatoid factor, anti-cyclic citrullinated peptide antibody, erythrocyte sed-imentation rate and C-reactive protein were also measured. Results: The frequency of rs34536443 minor allele (C allele) was not different between patients and control group [1. 7 vs. 2. 61 percent, OR (95% CI)=1. 35 (0. 78-2. 33); p=0. 27]. There was not a statistically significant association between rs34536443 genotypes and RA susceptibility. Genotypes of rs34536443 polymorphism were associated nor with demographic neither with serological features of RA patients. Conclusion: In the present study, there was not any association between TYK2 gene rs34536443 polymorphism with either disease susceptibility, demographic and serolog-ical features of Iranian RA patients. These findings are not compatible with previous works from other ethnicities, further supporting the role of genetics in disease suscep-tibility.

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APA: Copy

Mohamadhosseini, Azadeh, MANSOURI, REZA, JAVINANI, ALI, Ganjouei, Amir Ashraf, Akhlaghi, Massoumeh, ASLANI, SAEED, Hamzeh, Elham, Jamshidi, Ahmadreza, AHMADZADEH, NOOSHIN, & MAHMOUDI, MAHDI. (2019). Single Nucleotide Polymorphism of TYK2 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(2), 187-191. SID. https://sid.ir/paper/314029/en

Vancouver: Copy

Mohamadhosseini Azadeh, MANSOURI REZA, JAVINANI ALI, Ganjouei Amir Ashraf, Akhlaghi Massoumeh, ASLANI SAEED, Hamzeh Elham, Jamshidi Ahmadreza, AHMADZADEH NOOSHIN, MAHMOUDI MAHDI. Single Nucleotide Polymorphism of TYK2 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2019;11(2):187-191. Available from: https://sid.ir/paper/314029/en

IEEE: Copy

Azadeh Mohamadhosseini, REZA MANSOURI, ALI JAVINANI, Amir Ashraf Ganjouei, Massoumeh Akhlaghi, SAEED ASLANI, Elham Hamzeh, Ahmadreza Jamshidi, NOOSHIN AHMADZADEH, and MAHDI MAHMOUDI, “Single Nucleotide Polymorphism of TYK2 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 11, no. 2, pp. 187–191, 2019, [Online]. Available: https://sid.ir/paper/314029/en

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