Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats

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Azizidoost Shirin; NAZERI ZAHRA; MOHAMMADI ASMA; MOHAMMADZADEH GHORBAN; CHERAGHZADEH MARYAM; JAFARI ALIREZA; KHEIROLLAH ALIREZA

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Journal: Avicenna Journal of Medical Biotechnology Year:2019 | Volume:11 | Issue:3 Page(s): 234-238

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Title

Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats

Author(s)

Keywords

Brain

Cholesterol 24-hydroxylase

Diabetes mellitus

Ginger

Hydroxymethylglutaryl-CoA reductases

Abstract

Background: Patients with diabetes present with lipid disorders, including hypercho-lesterolemia, which can be a high-risk factor for atherosclerosis. Recently, increasing interest has been focused on anti-lipidemic function of herbal medicines, especially Zingiber officinale (known as Ginger), in diabetes. However, the mechanism underly-ing the effect of Ginger on some players involved in cholesterol homeostasis of Central Nervous System (CNS) among diabetic patients remains unclear. To our knowledge, this is the first study to investigate the effect of Ginger on Brain regulation of Hydro-xymethylglutaryl-CoA Reductase (HMG-CoA reductase) and Cholesterol 24-hydroxy-lase (CYP46A1), which provides a rational model for understanding Brain dyslipidem-ia mechanisms associated with diabetes. Methods: Brains of rats were isolated from four groups: control, non-treated diabetic, and treated diabetic groups receiving 200 or 400 mg/kg of hydroalcoholic extracts of Ginger for eight weeks. HMG-CoA reductase and CYP46A1 levels in Brain homoge-nates were determined by western-blot technique. Results: Ginger root extract caused a significant decrease in HMG-CoA reductase and an increase in CYP46A1 levels in treated diabetic groups compared to diabetic con-trol. In comparison to diabetic group, these effects were more remarkable with 400 mg/kg concentration of Ginger extract. Conclusion: The findings showed that Ginger extract has a regulatory effect on pro-teins involved in cholesterol homeostasis in CNS by a significant down-and up-re-gulation of HMG-CoA reductase and CYP46A1 levels, respectively. It can be suggested that adding Ginger to daily diet of diabetic patients has useful effects and may ame-liorate diabetes complications.

Cites

Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J

References

High-density lipoproteins at the interface be-tween central nervous system and plasma lipoprotein metabolism

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APA: Copy

Azizidoost, Shirin, NAZERI, ZAHRA, MOHAMMADI, ASMA, MOHAMMADZADEH, GHORBAN, CHERAGHZADEH, MARYAM, JAFARI, ALIREZA, & KHEIROLLAH, ALIREZA. (2019). Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(3), 234-238. SID. https://sid.ir/paper/314039/en

Vancouver: Copy

Azizidoost Shirin, NAZERI ZAHRA, MOHAMMADI ASMA, MOHAMMADZADEH GHORBAN, CHERAGHZADEH MARYAM, JAFARI ALIREZA, KHEIROLLAH ALIREZA. Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2019;11(3):234-238. Available from: https://sid.ir/paper/314039/en

IEEE: Copy

Shirin Azizidoost, ZAHRA NAZERI, ASMA MOHAMMADI, GHORBAN MOHAMMADZADEH, MARYAM CHERAGHZADEH, ALIREZA JAFARI, and ALIREZA KHEIROLLAH, “Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 11, no. 3, pp. 234–238, 2019, [Online]. Available: https://sid.ir/paper/314039/en

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