Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAZERI ZAHRA; Azizidoost Shirin; CHERAGHZADEH MARYAM; MOHAMMADI ASMA; KHEIROLLAH ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2021 | Volume:11 | Issue:5 Page(s): 473-483

Download Full-Text

View:

151

Download:

Cites:

Information Journal Paper

Title

Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J

Author(s)

Keywords

Garlic

Allicin

HMG-CoA reductases

ATP binding cassette transporter 1

CYP46A1

Abstract

Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of Garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear. Here, we investigated the beneficial effect of aqueous extract of Garlic and Allicin on lipid profile and the main players involved in brain cholesterol homeostasis including ABCA1, HMG-CoA reductase, and CYP46A1 in both C57BL/6J mice brain and astrocytes. Materials and Methods: Thirty mice were divided into control and Garlic groups. Garlic group was fed with the aqueous extract of Garlic. Serum lipids were measured and brain protein levels of ABCA1, HMGCR, and CYP46A1 were determined by western blotting. Changes in these proteins expression were also studied in the presence of Allicin in cultured astrocytes. Results: A moderate decrease in serum total cholesterol and a significant increase in plasma HDL-C levels (p<0. 05) were detected. A significant increase in ABCA1, HMGCR, and CYP46A1 protein levels was observed in the Garlic group and in the cultured astrocytes treated with Allicin by western blotting (p<0. 05). Conclusion: Our findings indicated that the main players involved in cholesterol turnover including HMGCR that is involved in cholesterol synthesis, ABCA1 that is important in cholesterol efflux, and CYP46A1 that is necessary in cholesterol degradation, were up regulated by Garlic/Allicin in both animal and cell culture model. We concluded that increasing cholesterol turnover is a possible mechanism for the beneficial effects of Garlic in cholesterol homeostasis.

Cites

No record.

References

Cite

APA: Copy

NAZERI, ZAHRA, Azizidoost, Shirin, CHERAGHZADEH, MARYAM, MOHAMMADI, ASMA, & KHEIROLLAH, ALIREZA. (2021). Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 11(5), 473-483. SID. https://sid.ir/paper/699881/en

Vancouver: Copy

NAZERI ZAHRA, Azizidoost Shirin, CHERAGHZADEH MARYAM, MOHAMMADI ASMA, KHEIROLLAH ALIREZA. Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2021;11(5):473-483. Available from: https://sid.ir/paper/699881/en

IEEE: Copy

ZAHRA NAZERI, Shirin Azizidoost, MARYAM CHERAGHZADEH, ASMA MOHAMMADI, and ALIREZA KHEIROLLAH, “Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 11, no. 5, pp. 473–483, 2021, [Online]. Available: https://sid.ir/paper/699881/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops