Importance of Fluctuating Amino Acid Residues in Folding and Binding of Proteins

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Senthil Renganathan; Usha Singaravelu; Saravanan Konda Mani

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Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biotechnology Year:2019 | Volume:11 | Issue:4 Page(s): 339-344

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Title

Importance of Fluctuating Amino Acid Residues in Folding and Binding of Proteins

Author(s)

Senthil Renganathan | Usha Singaravelu | Saravanan Konda Mani | Issue Writer Certificate

Keywords

Amino acid

Binding sites

Cell-penetrating peptides

DNA-binding proteins

Abstract

Background: Conformational flexibility of proteins remains as one of the major events in protein-protein/DNA/ligand/small molecule binding to achieve its biological function in the cell. The availability of high-resolution structures of protein complexes is a valu-able resource for researchers to understand the mechanisms behind such interactions and it is found that the flexibility of Amino acid residues at Binding sites is crucial for many important functions in the cell. Methods: In this article, our statistical method (PreFRP) developed based on fluctuat-ing Amino acid residues and various Amino acid indices related to flexibility/rigidity were used to study the importance of fluctuating Amino acid residues in thermonuc-leases from pathogenic bacteria, cell penetrating peptides and intrinsically disordered proteins responsible for many neural disorders. Results: The results from our analysis reveal the importance of fluctuating Amino acid residues in folding and binding of proteins. The role of moderate and high fluctuating residues in themonucleases, cell penetrating peptide and disordered regions are dis-cussed in detail. Conclusion: Therefore, our analysis will help in understanding the importance of fluc-tuating Amino acid residues in proteins which undergo a conformation change phe-nomenon.

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APA: Copy

Senthil, Renganathan, Usha, Singaravelu, & Saravanan, Konda Mani. (2019). Importance of Fluctuating Amino Acid Residues in Folding and Binding of Proteins. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(4), 339-344. SID. https://sid.ir/paper/314053/en

Vancouver: Copy

Senthil Renganathan, Usha Singaravelu, Saravanan Konda Mani. Importance of Fluctuating Amino Acid Residues in Folding and Binding of Proteins. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2019;11(4):339-344. Available from: https://sid.ir/paper/314053/en

IEEE: Copy

Renganathan Senthil, Singaravelu Usha, and Konda Mani Saravanan, “Importance of Fluctuating Amino Acid Residues in Folding and Binding of Proteins,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 11, no. 4, pp. 339–344, 2019, [Online]. Available: https://sid.ir/paper/314053/en

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