PLATELET GP IIB/IIIA RECEPTOR INHIBITION BY EPTIFIBATIDE IN NON ST-ELEVATION MI-ACUTE CORONARY SYNDROME

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MOMTAHEN M.; ABDI S.; JAVADZADEH F.; FARSAD B.F.; SHARIFIAN -; KAZAZI A.S.; MOMTAHAN S.

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Journal: INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL Year:2009 | Volume:3 | Issue:2 Page(s): 86-90

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Title

PLATELET GP IIB/IIIA RECEPTOR INHIBITION BY EPTIFIBATIDE IN NON ST-ELEVATION MI-ACUTE CORONARY SYNDROME

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Keywords

GP IIB/IIIA RECEPTOR INHIBITOR

EPTIFIBATIDE

ACUTE CORONARY SYNDROME

Abstract

Background: Recent trials of platelet glycoprotein IIb/IIIa receptor inhibitors have improved our understanding to best use these powerful antiplatelet drugs in ACUTE CORONARY SYNDROME. We tested the hypothesis that inhibition of GPIIb/IIIa platelet receptor with EPTIFIBATIDE is effective as an empiric therapy in patients with ACUTE CORONARY SYNDROME who do not necessarily undergo immediate revascularization.Methods: Since Feb 2006 one hundred and ninety-six patients who had presented with non ST-elevation ACUTE CORONARY SYNDROME (NSTE-ACS) were randomly assigned to receive EPTIFIBATIDE in addition to standard therapy, for up to 72 hours or routine standard therapy. The primary end point was composite of death and non-fatal myocardial infarction (MI) or urgent target vessel revascularization (TVR) in 30 days.Results: The incidence of composite end point of death, non fatal MI and urgent TVR was significantly lower in EPTIFIBATIDE group than standard group (16% vs. 0% - P value <0.01), particularly in troponin positive subgroup of patients (27.8% vs. 0% - P value <0.01).Any major adverse reaction such as major bleeding, stroke, or thrombocytopenia was not seen.Conclusion: Early administration of GP IIB/IIIA RECEPTOR INHIBITOR is recommended in patients with high-risk ACUTE CORONARY SYNDROME.

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APA: Copy

MOMTAHEN, M., ABDI, S., JAVADZADEH, F., FARSAD, B.F., KAZAZI, A.S., MOMTAHAN, S., & SHARIFIAN, -. (2009). PLATELET GP IIB/IIIA RECEPTOR INHIBITION BY EPTIFIBATIDE IN NON ST-ELEVATION MI-ACUTE CORONARY SYNDROME. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, 3(2), 86-90. SID. https://sid.ir/paper/314125/en

Vancouver: Copy

MOMTAHEN M., ABDI S., JAVADZADEH F., FARSAD B.F., KAZAZI A.S., MOMTAHAN S., SHARIFIAN -. PLATELET GP IIB/IIIA RECEPTOR INHIBITION BY EPTIFIBATIDE IN NON ST-ELEVATION MI-ACUTE CORONARY SYNDROME. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL[Internet]. 2009;3(2):86-90. Available from: https://sid.ir/paper/314125/en

IEEE: Copy

M. MOMTAHEN, S. ABDI, F. JAVADZADEH, B.F. FARSAD, A.S. KAZAZI, S. MOMTAHAN, and - SHARIFIAN, “PLATELET GP IIB/IIIA RECEPTOR INHIBITION BY EPTIFIBATIDE IN NON ST-ELEVATION MI-ACUTE CORONARY SYNDROME,” INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, vol. 3, no. 2, pp. 86–90, 2009, [Online]. Available: https://sid.ir/paper/314125/en

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