SUPPRESSION OF MYOCARDIAL INJURY MARKERS FOLLOWING PERCUTANEOUS CORONARY INTERVENTIONS BY PRE-TREATMENT WITH CARVEDILOL

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MOLOUDI ABDOLRASOUL; SABZI FERIDOUN; RASHIDI SHIRIN

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Journal Paper

Paper Information

Journal: INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL Year:2012 | Volume:6 | Issue:3 (20) Page(s): 88-91

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Information Journal Paper

Title

SUPPRESSION OF MYOCARDIAL INJURY MARKERS FOLLOWING PERCUTANEOUS CORONARY INTERVENTIONS BY PRE-TREATMENT WITH CARVEDILOL

Author(s)

MOLOUDI ABDOLRASOUL | SABZI FERIDOUN | RASHIDI SHIRIN | Issue Writer Certificate

Keywords

CARVEDILOL

TROPONIN I

CPK-MB

CORONARY INTERVENTIONS

Abstract

Background: Retrospective studies and clinical trials have indicated that b-receptor blockers have an influential role in improving survival and reducing risk of recurrent infarction in patients with myocardial infarction. However, there is still controversy regarding the effects of b-receptor blockers on the markers of myocardial infarction following percutaneous CORONARY INTERVENTIONS (PCI).Objective: The aim of this study was to evaluate the pre-treatment effect of CARVEDILOL on markers of myocardial injury in patients undergoing elective PCI.Method and Materials: In this clinical trial patients undergoing elective PCI were categorized randomly in the CARVEDILOL group including 100 patients who received two doses of 12.5 mg, 6 and 12 hours prior to PCI, and the control group (105 patients). Blood samples were obtained to analyse cardiac biomarker, 12 and 24 hours after PCI.Results: The clinical features were not significantly different between the two groups. A increase in the level of TROPONIN I was observed in the control group 24 hours following PCI (P=0.042), whereas this rise in TROPONIN I was slight and insignificant in the CARVEDILOL group (P>0.05). some difference was observed between the two groups in regard to the level of CPK-MB after PCI (P=0.041).Conclusion: The findings of our study indicate that pre-treatment with CARVEDILOL confers cardio-protection by limiting the rise of markers of myocardial injury following PCI.

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APA: Copy

MOLOUDI, ABDOLRASOUL, SABZI, FERIDOUN, & RASHIDI, SHIRIN. (2012). SUPPRESSION OF MYOCARDIAL INJURY MARKERS FOLLOWING PERCUTANEOUS CORONARY INTERVENTIONS BY PRE-TREATMENT WITH CARVEDILOL. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, 6(3 (20)), 88-91. SID. https://sid.ir/paper/314196/en

Vancouver: Copy

MOLOUDI ABDOLRASOUL, SABZI FERIDOUN, RASHIDI SHIRIN. SUPPRESSION OF MYOCARDIAL INJURY MARKERS FOLLOWING PERCUTANEOUS CORONARY INTERVENTIONS BY PRE-TREATMENT WITH CARVEDILOL. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL[Internet]. 2012;6(3 (20)):88-91. Available from: https://sid.ir/paper/314196/en

IEEE: Copy

ABDOLRASOUL MOLOUDI, FERIDOUN SABZI, and SHIRIN RASHIDI, “SUPPRESSION OF MYOCARDIAL INJURY MARKERS FOLLOWING PERCUTANEOUS CORONARY INTERVENTIONS BY PRE-TREATMENT WITH CARVEDILOL,” INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, vol. 6, no. 3 (20), pp. 88–91, 2012, [Online]. Available: https://sid.ir/paper/314196/en

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