Short Communication, Role of plasma levels of CA-125 in predicting outcome of primary PCI after acute myocardial infarction in male patients

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SEPARHAM AHMAD; ABBASNEZHAD MOHSEN; Shahnazarli Golnesa; Khoshbahar Alireza

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Journal: Journal of Cardiovascular and Thoracic Research Year:2018 | Volume:10 | Issue:2 Page(s): 109-112

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Title

Short Communication, Role of plasma levels of CA-125 in predicting outcome of primary PCI after acute myocardial infarction in male patients

Author(s)

SEPARHAM AHMAD | ABBASNEZHAD MOHSEN | Shahnazarli Golnesa | Khoshbahar Alireza | Issue Writer Certificate

Keywords

Acute Myocardial Infarction

CA-125

Outcome

Abstract

Introduction: Cancer antigen 125 (CA-125) is a tumor marker of ovarian cancer, which has shown to be increased in different cardiovascular diseases. Although the prognostic role of CA-125 in heart failure and coronary heart disease is well-established, there is little known about its role in Acute Myocardial Infarction (AMI). In this study we aimed to evaluate the serum levels of CA-125 in patients with AMI and its prognostic role in evaluating the in-hospital Outcome of AMI. Methods: We evaluated 120 male patients with AMI and 120 male normal subjects. CA-125 levels were measured upon the patient’ s admission to hospital. The in-hospital major adverse cardiac events (MACE) and its predictors were also recorded for AMI patients. Results: CA-125 levels were significantly higher in AMI patients compared to normal subjects (7. 99± 6. 83 vs. 5. 70± 4. 62, P = 0. 003). We found significant positive correlations between CA-125 levels with creatine kinase-MB (CKMB) (r=0. 621, P < 0. 001) and CTnI (r=0. 491, P < 0. 001). The in-hospital MACE was observed in 19 cases (15. 8%). Patients with MACE had significantly higher value of CA-125, CKMB and CTnI and lower LVEF compared to patients without MACE. CKMB (OR=0. 967, 95% CI [0. 943-0. 991], P = 0. 007) and CA-125 levels (OR=0. 821, 95% CI [0. 688-0. 979], P = 0. 02) were independent predictors of MACE. Conclusion: Serum CA-125 levels are significantly higher in male patients with AMI compared to normal subjects and have a significant role in predicting in-hospital MACE after AMI. In patients with higher CA-125 more aggressive treatment and close observation should be performed in order to reduce the possible adverse Outcomes.

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APA: Copy

SEPARHAM, AHMAD, ABBASNEZHAD, MOHSEN, Shahnazarli, Golnesa, & Khoshbahar, Alireza. (2018). Short Communication, Role of plasma levels of CA-125 in predicting outcome of primary PCI after acute myocardial infarction in male patients. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 10(2), 109-112. SID. https://sid.ir/paper/314968/en

Vancouver: Copy

SEPARHAM AHMAD, ABBASNEZHAD MOHSEN, Shahnazarli Golnesa, Khoshbahar Alireza. Short Communication, Role of plasma levels of CA-125 in predicting outcome of primary PCI after acute myocardial infarction in male patients. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2018;10(2):109-112. Available from: https://sid.ir/paper/314968/en

IEEE: Copy

AHMAD SEPARHAM, MOHSEN ABBASNEZHAD, Golnesa Shahnazarli, and Alireza Khoshbahar, “Short Communication, Role of plasma levels of CA-125 in predicting outcome of primary PCI after acute myocardial infarction in male patients,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 10, no. 2, pp. 109–112, 2018, [Online]. Available: https://sid.ir/paper/314968/en

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