New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota

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MOLUDI JALAL; ALIZADEH MOHAMMAD; LOTFI YAGIN NEDA; Pasdar Yahiya; NACHVAK SEYED MOSTAFA; Abdollahzad Hadi; SADEGHPOUR TABAEI ALI

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Journal Paper

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Journal: Journal of Cardiovascular and Thoracic Research Year:2018 | Volume:10 | Issue:3 Page(s): 129-137

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Title

New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota

Author(s)

Keywords

Atherosclerosis

Endocannabinoids

Gastrointestinal Microbiome

Probiotics

Trimethylamine-N-Oxide

Abstract

The incidence of Atherosclerosis is increasing rapidly all over the world. Inflammatory processes have outstanding role in coronary artery disease (CAD) etiology and other Atherosclerosis manifestations. Recently attentions have been increased about gut microbiota in many fields of medicine especially in inflammatory diseases like Atherosclerosis. Ineffectiveness in gut barrier functions and subsequent metabolic endotoxemia (caused by rise in plasma lipopolysaccharide levels) is associated with low-grade chronic inflammation i. e. a recognized feature of Atherosclerosis. Furthermore, the role of Trimethylamine-N-Oxide (TMAO), a gut bacterial metabolite has been suggested in Atherosclerosis development. On the other hand, the effectiveness of gut microbiota modulation that results in TMAO reduction has been investigated. Moreover, considerable evidence supports a role for the endocannabinoid system (ECS) in Atherosclerosis pathology which affects gut microbiota, but their effects on Atherosclerosis are controversial. Therefore, we presented some evidence about the relationship between gut microbiota and ECS in Atherosclerosis. We also presented evidences that gut microbiota modulation by pre/Probiotics can have significant influence on the ECS.

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APA: Copy

MOLUDI, JALAL, ALIZADEH, MOHAMMAD, LOTFI YAGIN, NEDA, Pasdar, Yahiya, NACHVAK, SEYED MOSTAFA, Abdollahzad, Hadi, & SADEGHPOUR TABAEI, ALI. (2018). New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 10(3), 129-137. SID. https://sid.ir/paper/314976/en

Vancouver: Copy

MOLUDI JALAL, ALIZADEH MOHAMMAD, LOTFI YAGIN NEDA, Pasdar Yahiya, NACHVAK SEYED MOSTAFA, Abdollahzad Hadi, SADEGHPOUR TABAEI ALI. New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2018;10(3):129-137. Available from: https://sid.ir/paper/314976/en

IEEE: Copy

JALAL MOLUDI, MOHAMMAD ALIZADEH, NEDA LOTFI YAGIN, Yahiya Pasdar, SEYED MOSTAFA NACHVAK, Hadi Abdollahzad, and ALI SADEGHPOUR TABAEI, “New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 10, no. 3, pp. 129–137, 2018, [Online]. Available: https://sid.ir/paper/314976/en

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