ACCURACY OF A NEW RAPID ANTIGEN DETECTION TEST FOR PULMONARY TUBERCULOSIS

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ALIANNEJAD RASOUL; BAHRMAND AHMAD REZA; ABTAHI HAMIDREZA; SEYFI MAHNAZ; SAFAVI ENAYAT; ABDOLRAHIMI FARID; SHAHRIARAN SHAHRIYAR

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Journal Paper

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Journal: Iranian Journal of Microbiology Year:2016 | Volume:8 | Issue:4 Page(s): 0-0

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Title

ACCURACY OF A NEW RAPID ANTIGEN DETECTION TEST FOR PULMONARY TUBERCULOSIS

Author(s)

Keywords

PULMONARY TUBERCULOSIS

DIAGNOSIS

RAPID TEST

Abstract

Background and Objectives: Tuberculosis (TB) is a major problem in the world. Treatment and control of TB needs detectionof the Mycobacterium tuberculosis (MT) in the proper samples. While smear doesn’t have enough sensitivity, cultureand PCR are expensive, time consuming and unavailable in many centers. Recent development of a rapid TB antigen detectiontest (PrTBK) at Pasteur Institute of Iran could give a simple way for DIAGNOSIS of TB in about two hours. In this test theantigen-antibody complex will change color when gold conjugated mouse anti- rabbit antibody detects specific MT cell wallantigen in suspected samples.Materials and Methods: We evaluated the diagnostic accuracy of PrTBK for DIAGNOSIS of pulmonary TB in comparisonwith smear, culture and PCR techniques in 56 consecutive samples (47 BAL and 13 sputum samples) obtained from patientswith clinical suspicion of active TB.Results: Twentynine patients (52%) were female and seven patients were HIV positive. PrTBK was positive in 17 culturepositive and 4 culture negative samples (100% sensitivity, 89% specificity and 92% accuracy in comparison with culturemethod). In two out of four patients with negative culture who were positive for PrTBK, PCR and anti-tuberculosis drugstrial therapy responses were in favor of tuberculosis. If we take this finding into account, the accuracy of PrTBK will rise.Conclusion: High sensitivity and accuracy of PrTBK test enable us to initiate treatment on the basis of this convenient andrapid test.

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APA: Copy

ALIANNEJAD, RASOUL, BAHRMAND, AHMAD REZA, ABTAHI, HAMIDREZA, SEYFI, MAHNAZ, SAFAVI, ENAYAT, ABDOLRAHIMI, FARID, & SHAHRIARAN, SHAHRIYAR. (2016). ACCURACY OF A NEW RAPID ANTIGEN DETECTION TEST FOR PULMONARY TUBERCULOSIS. IRANIAN JOURNAL OF MICROBIOLOGY, 8(4), 0-0. SID. https://sid.ir/paper/315408/en

Vancouver: Copy

ALIANNEJAD RASOUL, BAHRMAND AHMAD REZA, ABTAHI HAMIDREZA, SEYFI MAHNAZ, SAFAVI ENAYAT, ABDOLRAHIMI FARID, SHAHRIARAN SHAHRIYAR. ACCURACY OF A NEW RAPID ANTIGEN DETECTION TEST FOR PULMONARY TUBERCULOSIS. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2016;8(4):0-0. Available from: https://sid.ir/paper/315408/en

IEEE: Copy

RASOUL ALIANNEJAD, AHMAD REZA BAHRMAND, HAMIDREZA ABTAHI, MAHNAZ SEYFI, ENAYAT SAFAVI, FARID ABDOLRAHIMI, and SHAHRIYAR SHAHRIARAN, “ACCURACY OF A NEW RAPID ANTIGEN DETECTION TEST FOR PULMONARY TUBERCULOSIS,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 8, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/315408/en

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