Recent approaches in whole cell pneumococcal vaccine development: a review study

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MOHAMMADZADEH MONA; MAMISHI SETAREH; POURAKBARI BABAK; MAHMOUDI SHIMA

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Journal Paper

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Journal: Iranian Journal of Microbiology Year:2017 | Volume:9 | Issue:6 Page(s): 381-388

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Title

Recent approaches in whole cell pneumococcal vaccine development: a review study

Author(s)

MOHAMMADZADEH MONA | MAMISHI SETAREH | POURAKBARI BABAK | MAHMOUDI SHIMA | Issue Writer Certificate

Keywords

Streptococcus pneumoniae

Vaccine

Protection

Abstract

Despite the availability of relatively effective Vaccines, Streptococcus pneumoniae still causes widespread morbidity and mortality. Current Vaccines contain free polysaccharides or protein-polysaccharide conjugates, but do not induce Protection against serotypes that are not included in the Vaccines. Therefore, developing alternative Vaccines is of high priority and importance. Several investigators have identified protective antigens common to pneumococci of many or all serotypes. Malley et al. in their study, have recommended unencapsulated whole cells, as an alternative Vaccine, a number of such antigens unoccluded by capsule were presented in a native configuration in 2001. This review aimed at presenting this candidate of pneumococcal Vaccine and results in an animal model.

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APA: Copy

MOHAMMADZADEH, MONA, MAMISHI, SETAREH, POURAKBARI, BABAK, & MAHMOUDI, SHIMA. (2017). Recent approaches in whole cell pneumococcal vaccine development: a review study. IRANIAN JOURNAL OF MICROBIOLOGY, 9(6), 381-388. SID. https://sid.ir/paper/315529/en

Vancouver: Copy

MOHAMMADZADEH MONA, MAMISHI SETAREH, POURAKBARI BABAK, MAHMOUDI SHIMA. Recent approaches in whole cell pneumococcal vaccine development: a review study. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2017;9(6):381-388. Available from: https://sid.ir/paper/315529/en

IEEE: Copy

MONA MOHAMMADZADEH, SETAREH MAMISHI, BABAK POURAKBARI, and SHIMA MAHMOUDI, “Recent approaches in whole cell pneumococcal vaccine development: a review study,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 9, no. 6, pp. 381–388, 2017, [Online]. Available: https://sid.ir/paper/315529/en

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