مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

157
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

89
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

The effects of interaction of Dopaminergic and Kisspeptin neural pathways on Ghrelin secretion in rats

Pages

  29-35

Abstract

 dopamine, kisspeptin and ghrelin are important factors for regulating the reproduction and food intake. Finding the effective central or peripheral factors on ghrelin secretion attracted the attention of most researches. In the present experimental study, the effects of dopamine, kisspeptin and the GPR54 receptor signaling pathway role in the mediating the dopamine effects was determined on ghrelin secretion. Forty Wistar male rats weighing 220-250g in 8 groups received saline, 1nmol kisspeptin, 5, 15 or 45 microgram dopamine hydrochloride, simultaneous injections of 1nmol peptide 234 and kisspeptin, 15microgram dopamine and kisspeptin or peptide234 and 15microgram dopamine via third cerebral ventricle respectively. Blood samples were collected via tail vein. Mean serum ghrelin concentrations were determined by rat ghrelin kit and ELISA method. kisspeptin significantly decreased mean serum concentration compared to saline group, while 15 or 45 microgram dopamine significantly increased mean serum ghrelin level compared to saline group. kisspeptin significantly blocked the stimulatory effects of dopamine on ghrelin secretion compared to dopamine group. dopaminergic and kisspeptin/GPR54 signaling pathways may interact to control the ghrelin secretion at hypothalamic level. Stimulatory effects of dopamine on ghrelin secretions could exert partly via decreasing the activity of hypothalamic kisspeptin neurons.

Cites

References

  • No record.

    • Cite

    APA: Copy

    Sadeghzadeh, Azizeh, BAYRAMI, ABOLFAZL, MAHMOUDI, FARIBA, KHAZALI, HOMAYOUN, & ASADI, ASADOLLAH. (2018). The effects of interaction of Dopaminergic and Kisspeptin neural pathways on Ghrelin secretion in rats. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), 9(1), 29-35. SID. https://sid.ir/paper/315915/en

    Vancouver: Copy

    Sadeghzadeh Azizeh, BAYRAMI ABOLFAZL, MAHMOUDI FARIBA, KHAZALI HOMAYOUN, ASADI ASADOLLAH. The effects of interaction of Dopaminergic and Kisspeptin neural pathways on Ghrelin secretion in rats. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES)[Internet]. 2018;9(1):29-35. Available from: https://sid.ir/paper/315915/en

    IEEE: Copy

    Azizeh Sadeghzadeh, ABOLFAZL BAYRAMI, FARIBA MAHMOUDI, HOMAYOUN KHAZALI, and ASADOLLAH ASADI, “The effects of interaction of Dopaminergic and Kisspeptin neural pathways on Ghrelin secretion in rats,” ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), vol. 9, no. 1, pp. 29–35, 2018, [Online]. Available: https://sid.ir/paper/315915/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button